Allopurinol used for gout, 100 mg and 300 mg dosage and side effects are the main topics of discussion.
Hi this is josh i’m a pharmacist with pharmacist tips comm gonna talk to you a bit about the medication allopurinol and its uses in gout talk about the typical doses and side effects so specifically the topics we’re gonna cover include what what is i’ll appear and all the different uses for it dosage typical dosing potential side effects we’re going to discuss
Some of the warnings and also some of the drug interactions that we’re going to want to watch for so as all my videos informational purposes only not intended to serve as a substitute for your health care provider do not make any changes to your lifestyle medications etc without your health care providers approval so what is that appear in all it’s something
Known as a xanthine oxidase inhibitor what does that do well it prevents the conversion of xanthine to uric acid in the body uric acid is what collects in the joints and brings on those gout symptoms often presents in the big toe or other joints in the body where those crystals have built up and create a lot of pain in the us it’s was sold under the brand names
Ila prim i’m not even sure if the brand name is still available typical uses so gout is by far the most common use we see that for certain kidney stones now not all kidney stones only allopurinol only has uses in certain types of kidney stones so your your healthcare provider can determine whether the kind of stones that you have would respond to this therapy and
Then tumor lysis syndrome that is associated with certain types of cancer treatments the treatments increase the amount of uric acid so this helps clear that there’s certain situations where allopurinol is used for that what about the typical dosing more generally are started on 100 milligrams a day taken after a meal and of course we want to make sure plenty of
Fluids to help assist the body in excreting in excreting that generally then the doses increased by a hundred milligrams every two to four weeks and that until the uric acid level is achieved max dose is considered 800 milligrams a day typically i mean that it’s very rarely you’d need to go up to that most people somewhere between the 1 and 300 milligram dose per
Day is where you’re gonna see majority of people doses over 300 are generally split up so if you’re on 1 to 300 it generally can be taken once per day once you get up over 300 is recommended that it be split up doses are lowered you have some issues with kidney function that should course would be something your doctor would monitor what about the most common side
Effects as a whole it is generally tolerated really well most people don’t seem to have a big issue with it rash can occur in 2% or less there is potential when starting this to have a gout attack especially when therapy is first initiated it’s considered to occur in about less than 6% of people nausea 1% and serious kidney issues less than 1% so um pretty low risk
On all these and you know with proper monitoring and talking to your healthcare provider shouldn’t be too much of an issue what about the warnings you had need be cautious if you’re using the medications and per capita purine or a sathya prine the doses will need to be lowered not a lot of folks on those but if you are you need to your health care provider should
Be aware of that and adjust the dose as as needed there is a rare potential liver toxicity and like we touched on just a moment ago i can cause those acute gout attacks just during the initial phase generally and of course we want to maintain we don’t want to get dehydrated while we’re on this so maintaining fluids is very important rare bone marrow suppression can
Occur again that will fall into the monitoring category where your doctor can monitor your labs and watch for things like that and that drug interactions can occur so and we’ll talk about some of the common ones here and more amoxicillin and ampicillin penicillin antibiotics it could increase the risk of allergy and side effects from the antibiotic so a lot of times
They’ll change to another antibiotic but if they deem that’s the most appropriate you just need to be careful it could increase the risk of side effects ace inhibitors common blood pressure medications also there’s an increased risk of allergy or side effect they are sometimes used together it you know that’s a conversation between you and your healthcare provider
But we have to be mindful that can increase the risk of side effects of side effects is it the irene we touched on again that mean to reduce that dose carbamazepine also the levels of this could be increased by the allopurinol so that would be something that would need to be monitored cyclosporine mean that levels of that could be increased as well diuretics can
Increase the risk of side effects of allopurinol so that needs to be monitored and other drug interactions can occur there medications not used as frequently always important to make sure your doctor and your pharmacist are aware of all the medications you take so that it can screen for interactions i appreciate you watching i hope you like videos like these if
You do please like this video and subscribe to my channel and if you have any questions i didn’t cover about this medication go ahead and ask in the comments below and i will do my best to answer that for you thanks again for watching
Transcribed from video
Allopurinol for Gout 100 mg, 300 mg Dosage and Side Effects By Pharmacist Tips