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Atenolol versus Losartan in Children and Young Adults with Marfan’s Syndrome

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Ingles medico UCSG

Antenna load versus low certain in children and young adults with morphine syndrome first we have the definition morphing syndrome is enough to summon dominant disorder of connected tedious tissues affecting approximately one in five thousand people one cardiovascular disease mainly progressive or degree a dilatation and dissection is a leading cause of death

In marfan syndrome to remember the key characteristics and the important features i remember that miss marfan is tall m4 mitral valve prolapse which is a common risk factor for infective endocarditis eye for incisional hernias which are hernias and surgical site s for spontaneous pneumothorax s4 scoliosis and kyphosis which usually causes back pain in marfan

Patients m4 myopia with link subluxation a4 arch neurodactyly which is basically long fingers r for retinal detachment and f for flexible joints a for orgic aneurysm due to cystic media necrosis which is very common target of questions and finally n for numerous fractures the genetic cause is a mutation of the fibrin 1 gene which is located in chromosome 15.

And the most common cause of death is allergic dissection the angiotensin ii type 1 receptor blocker the certain has been shown to attenuate tgfb beta signaling in some disease states such as chronic renal failure and personally by decreasing the expression of tgfb ligand receptor and activators your heart pumps blood around your body through a network of blood

Vessels known as the circulatory system your blood then supplies the cells in your body with the oxygen and nutrients they need if your doctor has prescribed you beta blockers such as atenolol or bisoprolol it may be because you have an abnormal heart rhythm or angina or heart failure or had a heart attack beta blockers work by blocking the actions of hormones

Called adrenaline and noradrenaline these hormones make the heartbeat faster and with more force them makes your heart beat more slowly and with less force which reduces your blood pressure and the strain on your heart before you stop or change any medication even if you’re worried about side effects talk to your gp first as changing or missing a dose could

Harm your health for more information about beta blockers visit dot uk first we have the certain therapy is my a mice with marvin syndrome prevent elastic fever uh fragmentation and therefore preserve our tick wall architecture the certain also decrease the rate of arctic root and illustration into a small series of children with marfan syndrome and the

Rate of change in diarrhea as score over the three year period did not differ significantly between the athena law group and the los angeles so the nih marfan trial is going to be the biggest trial for marfan syndrome ever done it’s a trial that’s sponsored by the nih so it’s funded by the federal government and it’s being run by the pediatric heart network which

Is a research network that was started in 2001 to try to do research on kids with heart disease with a long-term goal of improving outcome the marfan trial was started in 2007. um and in the course of the trial we’ve recruited 608 young children and young adults half of the half of the subjects are getting a tennolol and the other half are getting lazartan we

Do know that children and young adults with marfan syndrome are tolerating both of these medicines very well in addition to trying to figure out which medicine is better at slowing your aortic enlargement we’re going to learn a lot about side effects of the medicines we’re going to learn whether these medicines are helping other parts of your heart your mitral

Valve your left ventricle we’re looking at the effect of these medications on growth on on your skeleton whether these medicines affect your pectus or your scoliosis so we’re going to learn a great deal not only about the effect of antennae and losartan on your heart but also on the rest of your body oh the raid of our group wrote one night with marfan syndrome

Treated with luster than was similar to that among wild type mice and was significantly less than that ammon on treated littermate with marfan syndrome also the better plunker pro panel also reduced the rate of 40 fruit growth among mice with morpheus marvin’s syndrome this effect was much less pronounced than that scene with version 10 in conclusion this trial

Involving children and young adults with marfan syndrome and arctic root and the location did not show the expected advantage of closer to an operational thanks

Transcribed from video
Atenolol versus Losartan in Children and Young Adults with Marfan's Syndrome By Ronald Calle Barzallo