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When we look at metabolic dysfunction we like to just think of ah we’re overweight things aren’t working really well but when you really look at metabolic dysfunction it’s not just about being obese or overweight it’s about being obese so overweight plus hyperglycemic having high blood glucose it’s also about having hyperlipidemia where your lipids are all out
Of whack cholesterols are all out of whack it’s also about being pre-diabetic or having insulin resistance and it also even factors in cardiovascular disease there’s a lot of things that we need to be looking at but one of the most important things that seems to be a big root of metabolic dysfunction is the mitochondrial dysfunction and there’s ways that we can
Kind of keep our finger on the pulse of it a little bit and i’m going to get into that but it’s very very interesting stuff in fact the institute of biotechnology the university of helsinki indicates that mitochondrial dysfunction could be the root of so many different diseases so mitochondria are more than just the energy powerhouses right they’re more than just
That okay they play a role in metabolic dysfunction and potential metabolic syndrome because when our mitochondria are dysfunctional they don’t just produce less energy when our mitochondria are dysfunctional they produce more oxidative stressors they produce more reactive oxygen species because they are the engine in our cells they are responsible for creating
That energy right for giving us the energy the atp but if that engine is dirty and not working properly it’s going to create a lot of excess exhaust and that triggers a lot of oxidative damage that can affect our aging acceleration that can absolutely have an impact on our ability to process fuels so it can impact insulin resistance it can impact pre-diabetes
All these things that are very important that we need to be paying attention to and maybe it’s all starting at the mitochondrial level so if we have an inefficiency in the mitochondria’s ability to process fuel okay if it can’t take electrons and create fuel out of it properly what’s going to happen well for one you’re gonna have less energy number two you’re
Gonna have more mitochondrial reactive oxygen species okay that’s gonna be more oxidative stress but as a result of that that actually damages the mitochondria more and when the mitochondria get damaged they leak particles and when they leak particles you have an increase in what’s called damage associated molecular patterns this means that the immune system
Has to deal with this damage and this damage that’s associated naturally with aging but even more so with metabolic dysfunction well this is going to trigger an inflammatory response when you have an inflammatory response well you can start listing off the potential problems that occur right this can definitely have an effect metabolically more inflammation can
Lead to well more insulin resistance it can lead to hyperglycemia can lead to less ability to utilize nutrients properly now again there’s things that you can do to monitor this we have to look at it like this okay our mitochondria are constantly bombarded with fuel we’re not supposed to always have fuel on hand now this doesn’t just mean overeating it means the
Instance of higher levels of blood glucose too like consistently eating and keeping our blood glucose levels high that’s not really supposed to happen when we have consistently high levels of fuel the mitochondria try to put a stop to it there’s actually some evidence that the reactive oxygen species the oxidative stressors that are produced in the mitochondria
There’s some theory that that entire process happens in essence to stop too many nutrients from coming in okay so basically what happens the mitochondria becomes dysfunctional so as a result it says well i’m going to increase insulin resistance to make sure that this cell doesn’t get more fuel because if it gets more fuel it’s going to cause a bigger problem to
The body so in a lot of ways the insulin resistance is protecting damaged mitochondria from releasing more reactive oxygen species it actually could be protecting a situation because we are so bombarded with nutrients one of the best ways to kind of modulate the negative effects of mitochondrial dysfunction is to put yourself in a deficit in a caloric deficit
Or to abstain from high glucose for a while so that from an energy standpoint glucose standpoint you are in a deficit what this does is it elevates what’s called ampk when you elevate ampk well amp k phosphorylates and it triggers the expression of pgc1a downstream from that you have more mitochondria that form so imagine this you have crappy little mitochondria
That aren’t doing a good job producing cruddy energy and lots of oxidative stressors well now all of a sudden you have gene expression that’s saying oh let’s go ahead and let’s break this cruddy mitochondria down and create better mitochondria that can process energy better that might have an impact on how glucose is utilized one of the ways that you can kind
Of manage this and take a good look at it is by continually monitoring your glucose so i wear a continuous glucose monitor i put a link down below for cygnus they are not just a way for every person to get a continuous glucose monitor but they provide the really interesting insight to allow you to do something with that data so yes i can look at my phone and i
Can get in real time my glucose reviews and i can see hey is my glucose too high am i potentially triggering mitochondrial dysfunction i can look at that and i can get a snapshot of that but it also has really unique algorithms to look at my trends look at what i eat and provide me with the insight to say hey your glucose is trending high it’s spiking high in
Order to prevent fat accumulation or potential damage you should go for a walk or you should do some squats or do some push-ups it gives me tips so that when i’m going throughout my life i get on demand things that tell me your glucose is high now i’m not saying that high levels of glucose are the only trigger for metabolic dysfunction but at a mitochondrial level
It is about nutrient sensing it is about our cells being able to recognize hey there’s too much glucose so now we start incurring damage right so i did put a link down below for signals that way you can try them out and you’ll save 20 off when you use that link so it’s cool you end up having like a quick telehealth consult that allows you to get your hands on
A continuous glucose monitor which isn’t easy to do in the first place you actually get a real continuous glucose monitor with like a dexcom device right and then you get the cygnus app that allows you to do all these cool things so really really cool opportunity so that link is down below again use that code on the screen right now and try that link out after
This video one of the things that we also don’t associate with metabolic dysfunction or mitochondrial dysfunction is how these higher levels of glucose and things like this can affect us from an aging perspective too okay this is very important to look at because if we are bombarded with super high levels of glucose all the time or just super high nutrients in
General like overloading of nutrients too many calories too much glucose things like that things we can monitor if we’re constantly bombarded with that well what happens is you have an increase in what is called the nad to nadh ratio this means that most of your electron carriers that would normally carry energy and all that they’re all occupied dealing with fuel
Now that sounds fine right because nad basically an electron carrier it’s occupied doing its job moving fuel but from an aging perspective when nad is not moving fuel it is activating sirtuins okay now let me put that in simple context when sirtuins get activated it increases our mitochondrial biogenesis because sirtuins also regulate mitochondrial physiology
So when we have less fuel less sugar less glucose less calories we have more available nad that can activate a sirtuin that then creates better mitochondria but it also doesn’t just do that it also triggers the expression of what’s called foxo3 which sounds like complicated gobbledygoo but it’s really pretty simple fox03 is known as the longevity gene because
It influences antioxidant production inside our bodies well what does this have to do with everything well imagine this imagine your mitochondria is dysfunctional and you’re not creating good energy so you’re creating a lot of reactive oxygen species a lot of oxidative stress if fox03 is expressed you’re producing more in the way of these natural antioxidants
That can deal with that stress it allows you to get a grip on the problem but you can’t really get a grip on the problem unless you are monitoring your nutrient intake and managing your glucose levels because again if you’re bombarded with fuel all the time and you’re insulin resistant the cells are just going to continue the mitochondria is going to continue
To get more and more dysfunctional produce you’re going to just downward spiral just to give you context into how much insulin resistance plays a role in mitochondrial dysfunction it is estimated that in people that are insulin resistant or type 2 diabetic that pgc1a expression is decreased 90 percent remember pgc1a is what allows for new mitochondria to form
So that is attenuated decreased by 90 percent in people that are insulin resistant or type 2 diabetic so obviously they would have high levels of blood glucose too this means that it is more difficult to produce new mitochondria when you are insulin resistant and it has all to do with again overloading this nutrient sensing the only way that we could possibly
Get a grasp on this that i can personally think of is to start bringing our cells into a deficit so that we phosphorylate ampk bring ourselves into lower glucose states so we can phosphorylate more ampk and increase the nad to nadh ratio but i have a few other ways that you could do this okay so number one put yourself in a deficit not all the time but as much
As possible intermittent fasting things like that those are very powerful tools to create an energy deficit energy deficits are not just about losing weight it triggers cellular changes and more mitochondria again i hope that’s getting across how important that is number two exercise which okay we know this right but if you were to be wearing a continuous glucose
Monitor for instance and you were to exercise you could watch what happens to your glucose this is another direction to activate ampk it’s another direction to go through mitochondrial adaptation you get these chronic adaptations that occur including pg c1a deacetylation which means more pgc1a being activated means more mitochondria so caloric deficit or fasting
But on a separate occasion outside of just that exercise exercise a lot and try to get that level up get that number up carnitine supplementing with carnitine can also be beneficial it does this because it helps remove the acyl coenzyme a toxic buildup and what that simply means is that it allows some of the toxic buildup in the mitochondria to be removed it
Sort of acts as a shuttle and that allows a already damaged mitochondria to maybe restore itself and get a little bit better now carnitine can also help suppress some of the fatty acid-induced membrane damage that can occur so carnitine is heavily published and i know it’s a supplement you don’t have to do it but i do recommend the occasional utilization of
Carnitine but you can also kind of increase your carnitine availability by occasionally going on like a ketogenic diet or doing lower carb now and then again not something you have to do something just to mention the next one is increasing glutathione levels in your body now you do this naturally in my opinion i’m not a big fan of glutathione supplementation
Eating sulfur-rich foods so things that are rich in like uh methionine right so methane rich meats so that’s going to be fish that’s going to be beef or rich in methane that’s very good for glutathione production okay additionally broccoli cauliflower brussels sprouts those are really good sulfur-containing vegetables that can drive up basically the conversion
Process glutathione needs sulfur to get activated another thing you can do as a supplement if you wanted to play around with it is going to be coenzyme q10 you can also eat foods that are rich in coenzyme q10 so again good healthy lean fishes lean meats things like that so coenzyme q10 acts like sort of a catcher’s mitt so that when the electrons are going down
Their electron transport chain they’re not bouncing all over the place creating reactive oxygen species there’s a larger mitt to catch them so it sort of corrals the electron transport chain process so that there’s less overall mitochondrial damage so that’s a good supplement if you’re looking to add something like that in also making sure you’re getting enough
Magnesium again either through supplement but ideally through food whenever you can it is a cofactor to catalyze a bunch of biochemical reactions that are involved in atp production so without magnesium you can’t really form atp so without magnesium you have less efficient mitochondria but by and large the best thing that you can do is just overall control your
Nutrient intake and keep a firm grasp on your glucose and keep a firm grasp on how much you are eating so as always keep it locked and here on my channel and i’ll see you tomorrow
Transcribed from video
Avoid the ROOT CAUSE of High Blood Sugar and INSULIN RESISTANCE By Thomas DeLauer