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Bisoprolol wikipedia article audio bisoprolol marketed under the trade name zubaydah among others is a medication most commonly used for heart diseases this specifically includes high blood pressure chest pain from not enough blood flow to the heart and heart failure it is taken by mouth side effects include headache feeling tired diarrhea and swelling in the legs
More severe side effects include worsening asthma blocking the ability to recognize low blood sugar and worsening heart failure there are concerns that use during pregnancy may be harmful to the baby bisoprolol is in the beta-blocker family of medications and is of the beta 1 selective type medical uses side effects bisoprolol was patented in 1976 and approved
For medical use in 1986 it is on the world health organization’s list of essential medicines the most effective and safe medicines needed in a health system bisoprolol is available as a generic medication the wholesale cost in the developing world is about two point nine eight to four us dollars and 94 cents per month in the united states as of 2015 it costs about
Twenty five to fifty us dollars a month bisoprolol is beneficial in treatment for high blood pressure reduced blood flow to the heart congestive heart failure and preventive treatment before in primary treatment after heart attacks decreasing the chances of recurrence bisoprolol targets hypertension in cardiac ischemia the drug is used to reduce the activity of the
Heart muscle so reduces oxygen and nutrient demand and reduced blood supply can still transport sufficient amounts of oxygen and nutrients bisoprolol can be used to treat cardiovascular diseases such as hypertension coronary heart disease arrhythmias ischemic heart diseases and myocardial infarction after the acute event patients with compensated congestive heart
Failure may be treated with bisoprolol as a comedic ation in patients with congestive heart failure it reduces the need for in the consumption of oxygen of the heart muscle it is very important to start with low doses as bisoprolol reduces also the muscular power of the heart which is an undesired effect in congestive heart failure overdose of bisoprolol leads
To fatigue hypotension low blood sugar bronchospasms and bradycardic bronchospasms and low blood sugar because at high doses drug can be an antagonist for beta-2 adrenergic receptors located in lung and in liver bronchospasm is due to blockage in lungs of beta 2 receptor and low blood sugar because of decreased stimulation of glycogenolysis and gluconeogenesis
In the liver via beta 2 receptor beta-blockers should generally be avoided in people with a history of asthma or bronchospasm as they may make the disease worse a beta 1 selective beta blocker like bisoprolol may be tried in those in whom other options are not available cautions bisoprolol is cardioprotective because it’s selectively and competitively blocks
Catecholamines stimulation of beta-1 adrenergic receptors which are mainly found in the heart muscle cells in heart conduction tissue but also found in juxtaglomerular cells in the kidney normally adrenaline and noradrenaline stimulation of the beta1 adrenal receptor activates a signaling cascade which ultimately leads to increased contractility an increased heart
Rate of the heart muscle and heart pacemaker respectively bisoprolol competitively blocks the activation of this cascade so decreases the adrenergic tone / stimulation of the heart muscle and pacemaker cells decreased adrenergic tone shows less contractility of heart muscle and lowered heart rate of pacemakers bisoprolol beta1 selectivity is especially important in
Comparison to other non-selective beta blockers the effects of the drug are limited to areas containing beta 1 adrenal receptors which is mainly the heart and part of the kidney bisoprolol minimizes the side-effects that might occur from administration of a nonspecific beta blocker where blockage of the other adrenal receptors occurs the other receptors elicit a
Variety of responses in the body and their blockage could cause a wide range of reactions but beta 1 adrenal receptors are cardio specific for the most part making bisoprolol ideal for treatment of cardiac events pharmacology bisoprolol has a higher degree of beta1 selectivity compared to other beta 1 selective beta blockers such as atenolol meta pro-law and bett
Axel all however never val all is approximately 3.5 times more beta one selective bisoprolol inhibits renin secretion by about 65% and tachycardia by about 30% bisoprolol has both lipid and water-soluble properties it has an approximate half-life of 1012 hours and when ingested has high bioavailability when being eliminated the body evenly distributes it between
Kidney excretion and liver biotransformation mechanism of action bisoprolol is available as a generic medication beta1 selectivity bisoprolol was patented in 1976 and approved for medical use in 1986 it was approved for medical use in the united states in 1992 rina nanji oh tenzin’s system pharmacokinetics society and culture this tree
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