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BS31004 – How Niclosamide and its Analogues Activate PINK1 GROUP 21

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Parkinson’s disease a new janitor disorder where by their loss of nerve cells and how the brain symptoms include resting tremors stiffness and slowness of movement until 2018 professor mckay and his colleagues investigated the possibility that an anti-parasitic drug could have therapeutic benefits in slowing down the early onset of parkinson’s disease through

The activation of pink wine p10 induced kinase pink one is a trans member mitochondrial kinase which had an important role in mitochondrial autophagy pink one activity called the parking protein to bind to depolarize mitochondrial membranes and he better to light them and tag them for autophagy failure in this pathway results in cell death via apoptosis due to

Elevated level of reactive oxygen species released by the faulty mitochondria unfortunately you’re incorrect it’s 1 in 37 it’s the aggregation of proteins and the deposit have helped us in their claim proteins know all of the drugs are used after courage events or they just help the symptoms but there isn’t a cure next we spoke to head research so it

Turns out of that so most patients who have mutations have either compound heterozygous mutations or homozygous mutations and and the most of these mutations are in the kinase domain so the protein is a 581 amino acids and the kinase domain spans between residues 152 about 513 and andrian others have actually shown that the mutations inactivate the kinase so

You disrupt kinase function no i think well i think as it is there’s many many challenges for example you know the drug would have to be you know that this drug probably not but but it but i don’t see an analogue we have to have better you know pharmacological properties in terms of absorption blood-brain barrier penetration but the actual mechanism seems to

Be uncoupling and that isn’t attractive i mean you know you what you might all be aware of these you know these are reports of young girls young women taking on couplers to lose weight like the cyanide phenol and actually they overdo it and effectively cause you know mini combustion in their abdomen so so these this is this is not this is not going to be in a

Viable for for drugs or scott for new drug development but i think what it does as i said before is it stimulates focus in this area the scientists involved in our chosen paper experimented using the alcohol mimetic drug the course amide in the hopes of activating pink one cells the cells were treated with different concentrations of mucosal might as well as

Anti mycenae together with oligo mycenae aka a additionally my sainted cells were immunoblotting to monitor pink one activity furthermore it was observed that the higher the concentration of in a course amide the great to the activation of pink horn cells the cells were also found to be activated to a greater degree with mucosal might than with ao this was

Observed via parkin phosphorylation fluorescence activated cell sorting was carried out on hello cells which showed that the causton wide and it’s analog am 85 promoted mitochondrial depolarization scientists therefore concluded with mucosal might and am 85 on copper metal and ria preventing the production of atp lastly scientists noticed that am 85 had a

Stronger effect on parker phosphorylation than the coastal mine however this effect was not explained by differences in uncoupling as both drugs had similar effects on mr. corneal depolarization in closing the research and experiments carried out found that the drug the chloride and it’s analog showed signs of activation of pink one at certain concentrations

It’s analogs therefore hold promise as a future strategy in the treatment of parkinson’s disease and related disorders however should be noted the further in vivo studies in parkinson’s disease models are needed to endorse this research you

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BS31004 – How Niclosamide and its Analogues Activate PINK1 GROUP 21 By Jemima Addai-Peprah