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Budesonide Is Effective in Adolescent and Adult Patients with Active Eosinophilic Esophagitis

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Drs. Straumann and Simon discusses their manuscript “Budesonide Is Effective in Adolescent and Adult Patients With Active Eosinophilic Esophagitis.” To view the print version of this abstract go to

Hello everybody this is professor alex trollman who is an adult gastroenterologist and director of the arizona village is of a guided study group in switzerland dr. stroman is responsible for the clinical issues within our team at this is professor hans ubuzima pharmacologist and immunologist director of the institute of pharmacology of the university of bern

Switzerland dr. simon covers the basic and translational research parts in our interdisciplinary group we were asked by the editors of gastroenterology to present our clinical trial analyzing the efficacy of the topical corticosteroid poo desonide in adult patients with eosinophilic esophagitis in the video the study was performed together with our colleagues of

The swiss it was an affiliate esophagitis study group and may be published within the next few months in the genre performing investigator driven studies in inflammatory diseases is one of our efforts to translate new aspects of basic science into clinical medicine our studies in ears and a filiger savage itís are a good example for this transnational approach

Which we chose to take in our institute why did we examine the effects of poo desonide in arizona village esophagitis we previously identified a synthetic as avid itís as a chronic th2 driven allergic disease of the esophagus in which arrow allergens and food allergens play a critical role however it is currently unclear how to treat these patients drugs diets and

Dilations have already been used but widely on an empiric rationale in children topical corticosteroids have been shown to be effective in placebo-controlled that is in contrast no placebo-controlled trials have so far been performed in adults we decided to test whether topical corticosteroid is able to bring patients suffering from ills and physical varieties in

Permission within two weeks of therapy the mission was defined histopathologically in this slide we marked arizona fills with a specific antibody so all the green cells are arizona foods you may appreciate the mark deadline of arizona fields after treatment compared with the levels before therapy patients did not only have reduced numbers of eosinophils they also

Improved in terms of symptoms this wager the leading symptom in adults markedly improved even within a few days as a ghast rental adjust i can also observe the inflammatory signs of this disease with pain the esophagus this is shown on this slide patients are characterized by white exudates android forums and corrugated rings interestingly budesonide treatment

Resulted in the disappearance of white exudates and red froze while corrugated rings persisted we conclude that white exudates and red furrows are reversible and signs of acute information whereas corrugated rings might be the consequence of chronic inflammation and remodeling processes because remodeling of surfaces could irreversibly damaged its function we

Thought that this process deserves special attention and investigation respectively be there for developed new biomarkers that appear to be useful for dark monitoring as shown on this slide we observed that the expression of tgf-beta by epithelial cell and the deposition of extracellular matrix port in tennyson see markedly decreased as a consequence of buddhism

8 therapy however whether these markers can predict long-term changes of the servitors needs to be investigated absolutely what we now need is to find out how to keep patients in remission in order to prevent flare-ups further damage and remodeling we have therefore added a budesonide maintenance study and hope that we can report our new findings soon

Transcribed from video
Budesonide Is Effective in Adolescent and Adult Patients with Active Eosinophilic Esophagitis By AmerGastroAssn