Free Pharmacology Resources:
In chapter seven we begin to talk about our endocrine system, and in this video specifically, we will be talking about our categories that we’ll be discussing in this video are going to be our tioamides and then two different types of iodine – we have our radioactive iodine and our non-radioactive iodine. our thioamides can be broken down into two different drugs – the brand
For that is tapazole, and then we also have our propylthiouracil which is commonly just abbreviated as ptu. our two different types of iodine as previously mentioned are our radioactive iodine, commonly referred to as radioiodine, and then our non-radioactive iodine, commonly referred to as ‘which medication is the safest for administration and does not lead to tolerance?’
That’s going to be a) methimazole. it’s going to be our safest option that does not lead to tolerance. and c) radioactive iodine are going to be the two options on this list that are going to have the highest b) propylthiouracil or ptu has a black box warning for some hepatotoxicity, and c) radioactive iodine isn’t really going to be the safest option either because it
Can lead to thyroid destruction – essentially that’s its main role is thyroid destruction so that can lead to some serious while d) non-radioactive iodine is a safer route than our ptu or radioactive iodine, it can lead to tolerance our next question is going to relate to ptu or propylthiouracil. for maintenance therapy and is associated with hepatotoxicity?’ when talking
About maintenance therapy, there are two medications on this list that we do not use for maintenance, and that’s going to be both of our iodine – our radioactive iodine and our non-radioactive iodine. our maintenance therapy medications are going to be limited to our methimazole or propylthiouracil. when it comes to maintenance, our methimazole is going to be used just
Once a day, and ptu or propylthiouracil is going to be used three times a day and it does have that black box warning for hepatotoxicity as well. it’s going to be c) radioactive iodine. it’s going to work to specifically destroy the thyroid gland, and there’s no specific known amount that it’s going to destroy until the patient comes back for a check-up, and the radioactive
Iodine might destroy too much of the thyroid gland and that could lead to a patient becoming hypothyroid and needing to take synthetic thyroid to correct for that long term. are going to work to inhibit thyroid hormone formation, and non-radioactive iodine is going to work as a negative feedback on the formation of thyroid hormones the last question that we have here is
Going to discuss the implications that non-radioactive iodine they’re mainstay therapies for patients that have hyperthyroidism. c) radioactive iodine comes in either a capsule or liquid formula, and that is also going to be a mainstay therapy for patients with hyperthyroidism. is going to be a solution that is administered in drops, however this is going to be an adjunct
Therapy for patients with hyperthyroidism. commonly, it’s used leading up to before the patient has their thyroid gland removed for surgery is typically when this medication is used.
Transcribed from video
(CC) Hyperthyroid Agents Methimazole vs Propylthiouracil vs Iodine Preparations By Tony PharmD