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CHX-Chlorhexidine Gluconate- explained by Dr. One Dintwe for

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Chlorhexidine Gluconate, also known as CHX is the gluconate salt form of Chlorhexidine. The name “chlorhexidine” breaks down as chlor(o) + hex(ane) + id(e) + (am)ine, and is a cationic poly biguanide.

Hi i’m dr hona dindway i hold a bachelor of science degree in biochemistry and microbiology as well as a phd in clinical sciences and immunology chlorhexidine gluconate also known as chx is the gluconate salt form of chlorhexidine chx is known for its effectiveness against a wide range of gram-negative and gram-positive vegetative bacteria yeast dermatophyte fungi

And lipophilic viruses because of its topical antibacterial activity chx is also used as an antiseptic agent it is used for skin disinfection before surgery and to sterilize surgical instruments chx has both bactericidal or bacterial static action against the wide range of gram-positive and gram-negative bacteria the term bactericidal means it kills bacteria

While bacteriostatic refers to its ability to inhibit growth even at low concentrations chx reacts with negatively charged bacterial cell surfaces destroying the integrity of the cell membrane once the integrity of the membrane is destroyed chx rapidly penetrates into the cell and causes leakage of the intracellular components leading to cell death gram positive

Bacteria are even more sensitive to this agent in higher concentrations the chx causes the cytoplasm to coagulate or solidify leading to cell death the mechanism of action against fungi is very similar to bacteria in a very short time the fungus takes up the chx which impairs the integrity of the cell wall and the plasma membrane and allowing chx to enter the

Cytoplasm resulting in leakage of the cell contents and cell death while many antimicrobial agents have a difficult time entering biofilms and eliminating organisms within the biofilm chx has shown some ability to inhibit the adherence of microorganisms to a surface thereby preventing the growth and development of biofilms biofilms are collected with one or more

Types of microorganisms that can grow on different surfaces in a polymeric substance they form a complex community of interactions and are contained within an extracellular matrix made of polymetric substances and proteins which protects the microbial cells and shields them increasing their resistance to antimicrobial agents according to a report written by the

Cdc unlike many other antimicrobials chx has demonstrated some effectiveness against microorganisms in different forms and states as well this includes bacterial spores and protozoa chx has also been shown to have activity against envelope viruses in vitro for example herpes simplex hiv cytomegalovirus influenza and rsv the advantage of chx is that it has broad

Spectrum efficacy as well as very limited irritation potential on the skin using chx in conjunction with ethanol in a solution has the added advantage of decreasing the evaporation time of the ethanol while increasing the overall product efficacy once the ethanol has evaporated chx matches all the regulatory standards with echa authorization to sell for biocidal

Use under article 95 and with the reach registration it is also registered with the cosmetic ingredient database which means that it can be used in cosmetics as a preservative with a maximum concentration of 0.3 according to many studies scientists have discovered that due to its positive charges chx binds strongly to skin mucosa and other tissues that is very

Poorly absorbed into our bloodstream no detectable blood levels have been found following oral use this means that this antimicrobial agent does not easily absorb into the skin but instead remains on the surface of the skin where it maintains its antimicrobial function historically methods of disrupting pathogen transmission have focused on improving healthcare

Workers adherence to recommended infection control practices a second complementary approach that was recommended was the decontamination of the patient’s skin as well at ecorad we use a dual strategy for killing microorganisms we pair the action of ethanol with the persistent effects of chx for a long lasting effect our swiping wipes are five times thicker and

Are packaged in bulk to maximize and enable the disinfection of any surface what if you could just swipe and wipe once and have the layer of protection reserved for surgeons only

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CHX-Chlorhexidine Gluconate- explained by Dr. One Dintwe for By EcoRad