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Coronary Plaque Regression and CV Risk

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How icosapent ethyl differs from other available omega-3 supplements in terms of efficacy and prevention against cardiovascular events.

Let me just ask you to elaborate just briefly in terms of it to me that seems like a lot of impact on total platform and platform russian rates and so forth especially when i think back to older i was studies i was involved with but maybe you could put into context for the audience how that does compare the other studies of plaque progression or regression yeah so

There were some studies out of japan that looked at other fish oil products other other iepa products i should say that that were also positive this is a more of a parallel group to what we what we studied and reduce it and this was obviously a u.s. population so i think it does add quite a bit to what we understand about this we’ve seen plaque excuse me we’ve seen

Black progression slowing or regression with statin therapy this is now again adding to statin therapy and evaporate and we see now further benefit so i think it is a supplementary to what we’ve seen in other other trials using cta or intravascular ultrasound if we if we parallel a more invasive technique that’s terrific and you just made me think of something

You said supplementary and that made me think of supplements and maybe i can ask dr. nabarro she’s thought a lot about these issues to speak a bit about how what we’re talking about and reduce it a prescription medication called ico semantical highly purified ethyl ester of epa or okosan pentanoic acid which is one of the omega-3 fatty acids how does that cosas

And death will differ from omega-3 supplements and is stuff that you can just go into the store and buy without a prescription and do those supplements offer any sort of benefit whatsoever in terms of cv risk reduction thanks dr. bot and this is really critically important because millions of our patients are taking supplement forms of fish oil an important thing

To know is that the fda does not regulate supplements in the same way that they regulate prescription or even over-the-counter medications supplements are essentially really regulated as food which means that the only time the fda will investigate safety concerns is if something is raised but there’s no prospective requirement for safety data for supplements

There is not the same level of quality control nor is there a mandate for effectiveness or efficacy data in the same way that we need from prescription drugs we’ve had two large publicly funded trials of fish oil in preventing cardiovascular disease and supplement forms of fish oil have never been shown to lower the risk of cardiovascular disease so these are not

Effective therapies and there’s a couple of reasons for this the first reason is that the dose of epa that you get out of a supplement is a fraction of the four gram dose that you get out of highly purified at cosa pentothal so you don’t get nearly the same dose as you would need at least based on what we saw in jealous and reduce it the second is that supplement

Fish oil literally is just squeezed fish taking the oil and putting it into a capsule and because the lack of quality control that often oxidizes it contains dha which can raise ldl as well as a number of other impurities and dr. preston mason has done a lot of work showing things like mercury content and other contaminants or things that you don’t want to put into

Your body from supplements so i think the reason why we see the differences is both in the amount of bpa the presence of other things and it’s critically important that our patients know that when they’re taking fish oil to try to lower their heart disease risk they’re likely not helping themselves they could be causing harm and as it relates to eligibility for a

Clothespin apple even though they do reduce triglycerides a little bit it might be just enough to make them not eligible for a cosa pentothal without actually giving them any sort of cardiovascular benefit so i strongly encourage my patience to reconsider the fish oil supplements that are taking unless there’s some other really strong reason that they personally

Want to take those yeah i think those are really important when saying the supplements tend not to be that cheap either so it’s not necessarily such a great thing to be taking something that’s not providing benefit and costing people perhaps displacing other evidence-based therapies that might otherwise be used

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Coronary Plaque Regression and CV Risk By AJMCtv