Skip to content

CYCLOSPORINE: Cyclosporine DOSAGE | Cyclosporine SIDE EFFECTS | Cyclosporine USES

  • by

💊All about CYCLOSPORINE medication: cyclosporine dosage (cyclosporine 50 mg, 100 mg), cyclosporine uses, cyclosporine side effects, cyclosporine contraindications, cyclosporine interactions, cyclosporine mechanism of action (moa), cyclosporine warnings. What is cyclosporine used for and what is cyclosporine?.

Hello welcome to my channel subscribe or dail like if you like today we are going to talk about the medicine cyclosporin we will explain its mechanism of action its side effects its dosage its uses its contraindications its warnings pregnancy and indications the trade names of cyclosporine are gengraph sand immune neoral sendimion send immunity oral siccorin

Mechanism of action of cyclosporine decreases the cellular immune response inhibiting the production of t-dependent antibodies it also inhibits the production and release of lymphocytes including interleukin 2. what is cyclosporine used for the therapeutic indications and dosage of cyclosporin are organ transplantation oral initial dose 10 to 15 milligrams slash

Kg per day in two doses during the 12 hours before transplantation and maintain one or two weeks maintenance dose two to six milligrams slash kg per day in two doses in administration with other immunosuppressors three to six milligrams kg per day in two doses intravenous perfusion two to six hours one-third of oral dose switch to oral route as soon as possible

Bone marrow transplant oral initial dose 12.5 to 15 milligrams kg a day in two doses starting day before transplantation maintenance dose 12.5 milligrams kg a day in two doses from three to six months then gradually decrease to dose zero intravenous perfusion two to six hours day before transplantation three to five milligrams kg per day maintain up to two weeks

Before switching to oral maintenance treatment endogenous uveitis oral initial dose five milligrams slash kg per day in two doses maximum dose seven milligrams kg per day may be associated with systemic corticosteroids 0.2 to 0.6 milligrams slash kg per day of prednisone or equivalent maintenance dose maximum 5 milligrams kg per day psoriasis oral initial dose 2.5

Milligrams kg per day in two doses if at month there is no improvement increase gradually maximum five milligrams kg per day if there is not a sufficient response in 6 weeks suspend maintenance dose maximum 5 milligrams kg day nephrotic syndrome oral initial dose five milligrams slash kg per day in adults or six milligrams slash kg per day in children in two doses

With renal insufficiency maximum dose to 5 milligrams kg per day if efficacy is not observed in three months discontinue rheumatoid arthritis oral three milligrams slash kg per day in two doses six weeks if the effect is not sufficient it can be increased according to maximum tolerance 5 milligrams kg per day if there is no efficacy at 6 months discontinue with

Methotrexate using initial doses of 2.5 milligrams kg per day in two doses which can be increased according to tolerance atopic dermatitis oral dose of 2.5 to 5 milligrams slash kg per day in two doses eight weeks maximum one year under monitoring mode of administration of cyclosporine capsules swallowed whole daily dose always distributed in two doses oral solution

Dilute preferably an orange or apple juice not grapefruit other non-alcoholic beverages may also be used daily dose always distributed in two doses contraindications of cyclosporine hypersensitivity to cyclosporine autoimmune diseases with altered adrenal function accept proteinuria in patients with nephrotic syndrome uncontrolled dts patients with psoriasis who

Are receiving other immunosuppressants puva uvd coal tar and radiotherapy side effects and adverse reactions of cyclosporine kidney dysfunction ets tremor headache including migraine paresthesia anorexia nausea vomiting abdominal pain diarrhea gingival hyperplasia liver dysfunction hyperlipidemia hyperuricemia hyperkalemia hypomagnesemia muscle cramps myalgia

Hypertrochosis fatigue cyclosporine warnings and precautions monitoring of cyclosporine liver and kidney function blood pressure potassium serum magnesium lipids caution in hyperuricemia with long-term methotrexate rheumatoid arthritis with other immunosuppressants lyrcanadippine case-bearing drugs case-bearing diuretics ace inhibitors angiotensin ii receptor

Antagonists or containing k risk of bacterial fungal parasitic and viral infections employ effective prophylactic and therapeutic strategy development of lymphomas and skin neoplasms avoid with live attenuated vaccines limited experience in children in elderly caution avoid excess sun exposure and in dermatitis with uvb radiation or puvophoto chemotherapy

Autoimmune diseases do not use an uncontrolled infections or malignant process liver failure and cyclosporine liver function monitoring may cause an increase in serum bilirubin and occasionally in liver enzymes which may require a dose reduction renal failure and cyclosporine contraindicated in autoimmune diseases with alt-adrenal function monitoring of renal

Function increased serum creatinine and urea at the beginning of treatment reduce the dose by 25 to 50 when the serum creatinine remains increased above 30 percent of the creatinine level recorded before starting therapy in more than one determination in nephrotic syndrome with alt adrenal function initial dose maximum 2.5 milligrams kg per day interactions with

Cyclosporine plasma level increased by macrolide antibiotics erythromycin azithromycin and clarithromycin ketoconazole fluconazole utriconazole vorkonasal deltiazem nicardipine varapamil metoclopramide oral contraceptives denizol methylprednisolone high dose allopurinol amiodarone ac colic and derivatives protease inhibitors imatinib colchicine plasma level

Decreased by barbiturates carbamazepine oxcarbazepine phenytoin naphthalene sulfadeemidine 4 rifampicin octreotide probiucol oralistat hypericum perforatum tyclopedine sulfon pyrozone terbinophene bozentan increased nephrotoxicity with aminoglycosides including gentamicin tobramycin amphotericin b ciprofloxacin vancomycin trimethoprim plus sulfamethoxazole

Nsaids including diclofenac naproxen cylindak melphalan histamine h2 receptor antagonists semetidine ranitidine methotrexate decrolimus reduces clearance of digoxin colchicine prednisolone and hmg coa reductase inhibitors statins and atopicide increased bioavailability due to concomitant intake of grapefruit juice increased gingival hyperplasia with nifedipine

Increased blood level of everolimus cyrillimus eliscurin increases the plasma concentration of repaglinide pregnancy and cyclosporine animal studies have shown reproductive toxicity in rats and rabbits experience with cyclosporine in pregnant women is limited pregnant women who are recipients of a transplant and who are being treated with immunosuppressants have

An increased risk of premature birth limited data are available on children exposed in utero to cyclosporine until about age seven in these children kidney function and blood pressure were normal however there are no adequate and well-controlled studies in pregnant women and therefore cyclosporine should not be used during pregnancy unless the potential benefit

To the mother justifies the potential risk to the fetus breastfeeding and cyclosporine cyclosporine is passed into breast milk so mothers on this treatment will stop breastfeeding you

Transcribed from video
CYCLOSPORINE: Cyclosporine DOSAGE | Cyclosporine SIDE EFFECTS | Cyclosporine USES By Medicines/Diseases