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Hi everyone welcome to researchmd.com we got another great presentation we’ve been doing a lot of uh videos on like the melatonin um and the effect of melatonin in this video we’re going to look at the melatonin and the blood sugar can you decrease the blood sugar in the patients with the diabetes that’s a clinical question we’re going to look at the scientific
Study and we’re going to tell you what did the science is saying all of our video is based on science-based evidence-based medicine okay and again my name is premier chariot i’m a program director internal medicine residency program transitional residency program i teach medical students in residence i do a lot of research i’m also a director of research and a
Muslim professor of medicine in two major universities so let’s get into our subject today and we’ll start with the melatonin what is melatonin it’s actually where is the production if the after in the retina this information come in like a luminous information that goes to the suprachiasmatic nucleus in the hypothalamus and the signal go to the pineal gland and
That any time when we get dark is the one right the signal come from right in a suprachiasmatic nucleus in the hypothalamus go to the pineal gland and tell them to secrete melatonin boom it’s secreted into your blood okay now pathogenesis or diabetes right um abnormal insulin in i mean sensitivity is the big issue hyperinsulinemia there’s going to be central
Obesity progressive loss of beta cell that’s where like the production and all that and then impair glucose tolerance which will lead it to diabetes okay you can also there’s some genetic factors for play we kind of make them genetic factors make the progressive loss of beta cells and there is physical inactivity kind of lead to central obesity and there’s high
Blood sugar kind of also all of this kind of effect and the make the patient high blood sugar and causing diabetes now how does melatonin help in diabetes what is the pathophysiology behind it let’s look into that in melatonin it works on the insulin receptor tyrosine phosphorylation what does it do that make insulin growth factor production increases okay it’s
Called igf so when you say when you have increased insulin in the body there’s like a better sugar control now the other ways you can help is like the main thing about melatonin every time we talk about melatonin we know the circadian rhythm the body clock and how does it regulate our sleep mechanism and all that same thing when a patient or when a person have like
You know this altered the circarian rhythm their sleep pattern is different their eating resting cycle is different and then all of this kind of contribute to increased insulin resistance increased blood sugar and diabetes so what does melatonin do it reset our circadian rhythm to like a normal like a regular 24 bio clock is going to be working fine so resetting
Of circadian rhythm or our biological clock that’s the main thing melatonin does also it also melatonin have some other effects also in the blood sugar they increase the body metabolism whenever metabolism goes up what happens our weight goes down right when we lose weight that decrease our blood sugar right that also induce insulin secretion with the signaling
Pathway and then it’s also improved better cell function so many many ways like you know if you look at the physiology how does it work um it is i mean you know it’s got a very good effect on controlling blood sugar now what did we do now we have to find a very good study to collaborate our uh you know physiology and is going to work in the clinical practice right
So we found this great study this is a meta analysis of randomized control studies when you look at the evidence and material is a randomized control study set the highest evidence okay and let’s see what we found out the objective of the study was to look at the investigate the effects of melatonin supplementation on diabetes for blood sugar control design this
Again we said there’s a meta-analysis with lots and lots of randomized control studies now the results the first one they look at it fasting blood sugar you can see it’s above on this side um so it is decreasing the fasting blood sugar very clearly melatonin based on this meta-analysis decreases fasting blood sugar now melatonin also decreased in hba1c level
Clearly shown in the study it also decreases hb a1c you can see the lowest diamond shifted to the left anything doesn’t touch zero is significant okay and what does it do to the insulin resistant melatonin also decreases insulin resistance also clearly seen in this graph also so looking at the strength of study again any time you have meta-analysis that’s a very
Good analysis very good scientific basis and of course you got a randomized control study that also this is the two major strengths of the study now in conclusion clearly in this based on this meta-analysis melatonin can decrease the fasting blood sugar can decrease hba1c and then it can decrease insulin resistance also okay thank you very much we’ll be back with
Another great presentation please help us our channel by subscribing so we can produce more videos like that again thank you
Transcribed from video
DOES MELATONIN DECREASE BLOOD SUGAR IN DIABETICS? Scientific analysis by Dr. Pramil Cheriyath MD By ResearchMD