Alright so in this video we’re gonna talk about loop a diuretics first i’m gonna quickly explain what that is so let’s draw a kidney first this is our nephron you so this is our nephron it’s maybe not the prettiest one but i think it gets the job done so the important thing to for you to remember is that in the nephron this is the thick part as you can see and
In the lumen of the thick part you have a a pump it’s called the sodium calcium and potassium pump so it pumps out sodium calcium put sodium calcium and potassium it brings them out now you have cells of course lining lining this proximal tubules so i’m just drawing one big cell so you have an idea and on the other side of the cell you have a another pump and this
Pump is the sodium calcium pumps i’m gonna put calcium in a different color just to make it easy for you it’s aureum calcium pump and the idea is that you have sodium calcium and sodium calcium protections that are leaving the cell and the the sodium goes goes across and it crosses over into the blood potassium comes in now so the thing to remember is that you
Have these back channels back channels that are always pumping potassium out so the the the potassium is coming back into the cell as you can see because the potassium comes back into the cell the cell ultimately has a net positive charge here because there is such a big positive charge you have other other cations like calcium like magnesium that are eventually
Driven away because there’s so much positive charge that they have to be driven away just escaping that positive charge sorry this is getting a little messy but now what what these drugs do is that they inhibit this they inhibit the sodium calcium and sorry sodium potassium and chloride pump so what happens is that they completely inhibit this this does not happen
Anymore and what that means is that you don’t have what what that really means that you don’t have a positive charge there’s net positive charge the calcium doesn’t need to come back in so there’s no net positive charge in the lumen for that reason the for that reason the soul/the the calcium and the magnesium do not need to move out because there is no positive
Charge there’s no positive force driving them out so as a reason you have loop diuretics these are called loop diuretics diuretics oh my gosh i don’t know how to spell terrible so you have these loop diuretics this is why they are loss of calcium magnesium so you can see that it caused hypocalcemia also you can see that because there’s no sodium sodium is lost as
Well so for that reason you have sodium is lost or stays in the lumen and hence the water stays wasted wasted as well so this is basically how luke diuretics works some of the names of these drugs are for awesome ide there are some id to tourism i’d you might add in view maternity and it’s a cry make acid so there you have it this is a loop diuretics basically as
We can see what event what actually happens is whoops sorry about that so as you can see here what happens is that you have sodium calcium potassium and chloride going in going into the body sodium comes sodium comes out chloride potassium comes in they’re leaky channels to liga channels the the potassium comes back into the cell because it coming back into the
Cell makes the cell positive you have magnesium calcium that is so positive that they have to be driven out somehow they have to be driven out now when you block these drugs there is no then you block these drugs there is none of this happening so you don’t have the positive charge for that reason you lose the calcium you lose the magnesium when i say lose the
Magnesium and lose the catcher meaning that you pee it out it doesn’t go inside the body you don’t have sodium is lost water sodium is lost or it stays in – in the lumen or in the – in the in the nephron for that reason because sodium is there water is there and hence this is called loop diuretics
Transcribed from video
Drugs LoopDiurectics By Amber MedStudent