Explain epinephrine cascade and how many molecules activated in each step of signal transduction. Epinephrine is a medication that acts on adrenergic receptors. Commonly used in anaphylaxis and cardiac arrest.
Good morning everyone welcome back in my youtube channel microbial 2020. today i will explain the topic epinephrine testing the model for a philippine cascading we know about the epinephrine ethernet trina is the ligand bind to the receptor addressing the binding of epinephrine to the site on the receptor dips it in the plasma membrane that promotes the
Conformational changes in the receptor uh that is the intracellular domain that affects its interaction with an associated g protein and promoting the dissociation of gdp and binding the gtp from the cytosol we know about that but uh beta adrenergic pathway in which the uh fingerprint is used okay uh this is the model for the epinephrine cascading uh in this the
Epinephrine triggers the series of reaction in hepatocyte in which the catalyst activates the catalyst this catalyst activates the catalyst again this catalyst activates this catalyst again this active uh catalyst activates another catalyst that is if an efferent triggers the series of reaction in phytosite in use the catalyst activates the catalyst resulting
In the amplification of original hormone signal that is the amplification of original hormone signal means the transmission of message from cell surface with the help of amplification the number of molecules shown are simply to illustrate the how to work amplification and our amplification and number of which one number of molecules activated which are the
Number of molecules activated see the binding of one molecule of epinephrine to the one beta and energy receptor on the cell surface okay that activates the many that is possibly the hundreds of g proteins and one after another each of this g protein which goes on to activate the adenylyl cyclase each of this g protein goes on to activate the adenylyl cyclase
And this one molecule of adenylyl cyclase acts catalytically and producing the molecules of cyclic amp from atp okay then these two of cyclic amp are required to activate the one molecule of protein kinase a catalytic subunit i have already told about the ephemeran triggers the reaction catalyst activates the catalyst okay the cyclic amp activates the protein
Kinase a again this protein kinase a activates the phosphorylase kinase then again this phosphorylase kinase activates the phosphorylase b and then from this phosphorylase b molecule of phosphorylase b activates and converts the ah converge the glucose from glycogen this is the process of amplification also model for the symmetry cascity ephemerin binds to the one
Molecule of ephemerin binds to the receptor then activate the g protein then activate the adenylyl cyclist this adrenal cyclase activate the cyclic amp the encyclic mp again and use for the activation of the protein kinase a then protein kinase activates the phosphorylase kinase and phospholipid is the phosphorus kinase activate the phosphorylase b and from this
Phospholipid the production of the glucose from the glycogen this is about the model of affiliate gasketing next one is the cascade that is amplification uh means uh which transduction step activates the how many number or how many molecules number of molecule see here uh it is the enzyme in enzyme its system amplifies the biological signal a very small number
Of polar molecule makes a choice to trigger the production of enzyme molecule that catalyze the reaction are tense over the hundred of substrate molecule for example a single molecule of if in a frame binds to the receptor one molecule of uh receptor form the infiniferent receptor complex and activated and trigger the adenylyl cyclase activated and trigger the
Adenylyl cyclase with the help of g protein in a cytosol of the plasma membrane okay then this adenylyl cyclase catalyze cyclist makes the catalyze the information of hundred molecules of cyclic amp from atp okay this adenylyl cyclase makes catalyze the information of the hundred molecules of cyclic amp from atp then each of these each of these cyclic amp can
Activate and can catalyze the molecule and can catalyze and reactivation of molecule protein kinase a okay then same each of these protein kinase molecule make catalyze the reactivation of hundred molecule of phosphorylase b kinase what is from protein kinesis each molecule of protein kinase a make catalyze the reactivation of the phosphorylase 100 molecules
Of the phosphorylase b thymes then from these each of those molecules make catalyze ah catalyze the reactivation of hundred molecules of glycogen phosphorylase a glycogen phosphorylase a and then each of these sorry each of those molecules make catalyze and conversion of the 100 molecules of glycogen 100 molecules of glycogen to glucose one phosphate what
Each of these each of these each of those molecule makes catalyzed make catalyzed and conversion of glycogen conversion of the the glycogen conversion of the glycogen to the glucose one phosphate and this glucose one phosphate that is glucose transfer to the blood this is the uh this is the cascading effingham cascade and that of 100 that of the 100 million
Of like 100 million of the glucose molecules are each molecule of risk are the response of each molecule of if in a frame means one molecule of if in a frame carry the signal transduction process as amplification and step by step activates the catalyst step by step catalyst activates the catalyst and response is a number of molecules of glucose got it this is
The infinite cascading then this whole figure shows the outline of if in a friend cascade and the each transduction step activates the how number of molecules and which one which is the uh which is the response of the ephemerin cascading this is the first primary step reception how to bind up in a principle g protein one molecule dense transduction process uh
Transduction procedure carried step by step and response obtained as a glucose one phosphate about the 10 is to eight molecules this is all about the uh outline of infinitely cascading then summary of this cascade the enzyme cascades in which the single molecule of hormone activates the catalyst to activate the another catalyst and process carried and so on
Result in the large signal amplification that is characteristic of hormone receptor system got it thank you now now i will stop here so you
Transcribed from video
Epinephrine II Adrenaline II Cascade Tutorials By MicroBial2020