Skip to content

Fexofenadine – GPCR pathway

  • by

Hello today i’m going to briefly talk about the signal pathway effects offending so what is flexophenetin flexoplaning is a drug that reduces allergy symptoms this type of drugs is known as antihistamines as we can see from the chemical formula it has complex chemical makeup including a pretty nitrogen group carboxylic acid curb and two hydroxyl groups it is

The second generation antihistamine meaning that it is not able to cross the blood-brain barrier vexofendin is called a neptune blocker because it acts as an antagonist by blocking the action of histamine as mentioned before vexofending is mainly used for allergies this includes upper respiratory allergies allergy symptoms such as sneezing itching runny nose and

Watery eyes it is also used to help with similar symptoms in skin conditions in humans as well as some animals there are some mild side effects of this drug including headache nausea back pain as well as drowsiness but as mentioned before facts offending is unable to cross the blood band barrier unlike most antihistamines which belong to first generation group

This means that the drowsiness caused by flexophenidines is comparatively much milder than its alternatives so how does taking this drug relieve our symptoms the answer is g protein coupled receptor pathway but before we go into that you should be aware that all cells are surrounded by a phospholipid bilayer which acts as soldiers that prevent entry and exit of

Molecules in and out of the cell due to this all drugs must be manufactured with the ability to bypass or treat these soldiers as this name suggests anything here it contains a phosphate head and fatty acid tails and is arranged in two or y layers the reason for this arrangement is because the phosphate head is hydrophilic meaning that it is attracted to water

Whereas the tails are hydrophobic making them repel water as a result all the heads face the water and all the tails face inwards to get as far away as they can from the fleets here’s a 3d animation to show the membrane but you can see it has a fluid mosaic structure it’s always waving now it should be noted that this bilayer has certain structures embedded in

Them such as cardioproteins and enzymes again here’s a 3d version to help you get a better idea of this finally moving on to the pathway taken by flexophenidine here in green is the g protein coupled receptor below this receptor is a g protein which is made up of an alpha beta and gamma subunits as in above it also has an opening that acts as the binding site

For incoming ligands such as flexophenidine when fexofending binds it activates the g protein and separates the alpha unit from its beta and gamma counterparts it should be noted the phexophagon does not enter the cell it merely passes that information across in its active state g protein is able to move towards the enzyme and activate it into producing secondary

Messenger cells these messenger cells then diffuse towards the target protein end of kb and inhibits its activity as a result immune response is decreased and decrease in histamine alleviates allergy symptoms that’s the end of the signaling pathway however please note that this is an extremely simplified version and excludes additional signaling pathways of

Exophilidine such as reduction of calcium ions via pap to signaling pathway thank you for listening and i wish

Transcribed from video
Fexofenadine – GPCR pathway By Azla D20A0049