Glucagon Like Peptide-1 Agonists for Type II Diabetes.
Hi everyone thank you for joining me today my name is vivian wynn i’m a candidate of pharmacy class of 2021 and today i will be going over a class of medication called glucagon-like peptide one receptor agonist commonly referred as glp-1 receptor agonists first i will be going over some patient counseling points all glp-1 receptor agonists are given as a subcutaneous
Injection in the stomach area arbor lakes such as a thigh or back of the upper arms make sure to tell patients to rotate their injection site they can be given without regards to food the two exceptions are byetta and efflux in which can be given within 60 minutes and meals the most common side effects that patients may experience are nausea vomiting diarrhea and
Headaches this medication can cause pain and inflammation in the pancreas patients should stop taking it and let their healthcare provider know if experiencing severe stomach pains with or without vomiting the pain can radiate from the abdomen through to the back as for storage do not store a pen with needle attached remove the needle from the pen immediately
After injection this can help prevent any leakage of the medication from the pen and also air bubbles performing in the cartridge pen injection devices should never be shared even when the needle is changed due to risk for transmission of blood-borne pathogens keep pens and needles out of reach of children and pets it’s also important to let the patient know that
The medication should be refrigerated until they are ready to use the pen now we will be going into detail about the glp-1 receptor agnes here is a formal introduction of these drugs g-o-p one receptor agonist are also known as increasing mimetics these medication are used in addition to healthy eating and physical activity to lower blood glucose levels in people
With type 2 diabetes as you can see there are several different kinds of glp-1 receptor agnes available all can you use alone or see with other medicines the short-acting glp-1 receptor agonist includes eggs anna tyne buy yet o which is dose twice daily lick senate side ad licks in which is dose once daily and long-acting glp-1 receptor agonist includes liraglutide
Victoza which is dose once daily the res will be dosed once weekly and these includes doula glue tired which is known as trulicity eggs and tight extend release which is known as by tyrion and semi glued side which is known as o’s empik there are pros and cons to using a glp-1 receptor agonist the pros of using a glp-1 receptor agnus are that it does decrease a1c
From 0.5 to 1.5% it does cause weight loss and some even contain a cbd benefits the most being liraglutide then semi gluten and then exhibit id extended release liraglutide does contain renal benefits the constabies medication is it comes in an injectable form while other comes in oral form another factor to consider is cost gop one receptor agonist are pricey
Compared to swine alleles and metformin now we’re going to take a look at their mechanism of action some people with type 2 diabetes also do not make enough of a family of hormones called egerton then click gastric inhibitory peptide gip and glucagon-like peptide 1 glp-1 receptor the increments are released from the gut or intestine after eating gop 1 receptor
Agonists are a class of meditation that copy the action of naturally-occurring glp-1 when gop 1 medications are released in the body they do four things to help decrease blood glucose or blood sugar levels the first is that they increase glucose dependent insulin secretion insulin needs to be released when eating so that glucose from the meal can be used this
Helps keeps blood glucose levels stable during meals second they slowed down stomach emptying gop 1 medications help keep food in the stomach longer that way the body can absorb food better as it moves slowly through the intestine third they reduced we got secretion glucagon secreted from the pancreas tells the liver to send glucose into the bloodstream this helps
Keeps blood glucose level stable between meals forth and improved satiety which can result in weight loss increasing receptor in the brain receives a signal so that the body knows it is time to stop eating focusing on dose adjustment with these medication we really don’t need to worry about any dose adjustment for patients with hepatic problems but renal function
Needs to be measured prior to initiation and monitored closely during therapy in patients taking eggs anna type vai että and eggs and it’s had extended release by giri on it is not recommended in patients with end-stage renal disease or aquatic clearance less than 30 also in lick sanitize licks in it’s not recommended in patients with egfr less than 15 earlier
We’re able to cover a common side effects but now we’re going to go into more details with their adverse effects with these medication the adverse effects include nausea vomiting diarrhea constipation antibodies a large portion of patients develop antibodies to exhibit id however there were no obvious consequences for its therapeutic efficacy patients also develop
Hypoglycemia weight loss and injection site reaction wanting and precaution with this class of medication is that they do have a blackbox warning their blackbox warning applies to all except byetta and ethics in they have a risk of thyroid c cell carcinoma which was seen in rats but unknown address applies to humans avoid in personal or family history of medullary
Thyroid carcinoma and teasing or patients with multiple endocrine neoplasia syndrome type 2 men – it can cause pancreatitis can be fatal usually in patients with risk factors of history of pancreatitis gallstone alcoholism or increased triglyceride this medications are not recommended in patients with severe gi disease including gastroparesis drug specific warning
And for is that by geryon causes serious injection like reaction suggest abscess cellulitis necrosis with or without subcutaneous nodules hos empik can increase complications with diabetic retinopathy and trulicity can cause cardiovascular events such as tachycardia first-degree av block or pr interval prolongation in patients who are starting these medications
Some important monitoring parameters for efficacy or a1c they should get it at least twice yearly in patients who have a stable glycemic control in our meeting treatment goal in quarterly in patients not meaning treatment goal or what therapy changed they should also monitor blood glucose for efficacy for safety monitoring check patients renal function especially
In patients taking exhibit id and lick senate id sign the symptoms of pancreatitis iron ra patients taking workmen in calcitonin levels for signs of medullary thyroid cancer these are my references thank you so much everyone for listening and i hope you guys enjoyed
Transcribed from video
GLP-1 Agonist Class for Type II Diabetes By Riverside Rx Services