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Heparin | Anticoagulant | Blood | Pharmacology | Med Vids made simple

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Heparin is an anticoagulant which is used for so many years. Watch this video fully to learn how Heparin works, its uses, side effects and much more!

In this video we’re gonna see about heparin happen is a anticoagulant it basically prevents the coagulation of blood so in patients who are at more risk of developing blood clots or coagulation anywhere in their body heparin is a drug or we can study the other way heparin is a lifesaver in those cases heparin can go to that side and then it can prevent the coagulation

By doing so the parent can save the life of the patient so a parent is an anticoagulant which prevents coagulation of blood heparin is an indirect robbing inhibitor why is it called so so this is basically to deal with the mechanism of action of heparin which i will be talking about in the next slide heparin binds to something known as antithrombin 3 and these two

Together form a complex which inhibits the clotting factors thrombin clotting factor 10a and clotting factor 9a so as you can see here heparin doesn’t go straight to thrombin and inhibited whereas it binds to end antithrombin 3 and then these two together inhibit trauma that’s why it is known as indirect trauma inhibitor check so there are various types of heparin

This includes an fractions a parent which is also known as high molecular weight heparin low molecular weight heparin and fonda paraben x4 no paradox is basically a synthetic heparin so now let’s about the advantages of low molecular weight heparin over infraction or high molecular weight heparins low molecular weight her parents are relatively safer compared to

Unfractionated rates and the bioavailability of low molecular weight her parents is more compared to high molecular weight of parents due to various factors such as increased half-life and that low-molecular-weight parents and need not be administered so many times compared to high-molecular-weight her parents and one more difference between these two is that

High molecular weight heparins require frequent monitoring of the drug in the patient or white side effects whereas low molecular weight heparins need not be monitored in patients so frequently except in few cases such as in pregnant women and patients with liver disease etc so these are a few low molecular weight heparin so this includes an ox operon and delta

Pairing so it’s so easy to remember these two drugs as you can see here the last five letters in these two drugs or pa ra n which is pairing which is derived from heparin that makes your life easier here it’s so now let’s come to the toxicity part so it’s so easy to remember the toxicity of heparin because heparin inhibits the coagulation in the patient and when

That goes out of control the patient can wait so much so that the patient can even bleed to death so everything needs to be in control when you treat a patient with heparin and you need to carefully select a patient when you’re gonna kill a parent to that patient another side effect with heparin is alopecia and this is not so common but still it can happen in few

Patients alopecia is nothing but hair loss when you do parent a patient for a long period hair loss can occur another most common side effect of heparin when you give the patient with heparin on a long term is osteoporosis this is nothing but weakening of bones so if you have osteoporosis you need to be more careful and if you fall even mind you and trauma can

Lead to significant fractures so now let’s go now let’s discuss about one of the very important adverse effect of heparin however this is not so common but still it’s very important to know it is known as heparin induced thrombocytopenia hid in short so whatever you have perrin busy in the first place heparin is given to control the hyper clad liberal state of

The patient but in a few patients what happen is the contrary thing happens the patient will start to develop system with hyper credible state which means the patient will start to develop venous trimble if not so at least in the veins in the distal restore extremities such as near the feed and all that so in few extreme cases even skin necrosis can occur so you

Need to consider this adverse effect when you treat a patient with a parent so how do you manage happen induced thrombocytopenia basically you stop you stop giving a parent further and then you need to give a direct thrombin inhibitor so in this video i’m not gonna tell anything about direct raman inhibitor because i need i’ll be making a separate video on that

Very soon so stay tuned for that so there are a few conditions where you can give apparently the patient so there are obviously few contraindications and this includes apparently of thermoset opinion acute bleeding severe hypertension and hypersensitivity to heparin there is a massive list of contraindications to give contraindications to giving a parent but i’ve

Just taken the four most important things out of those and these four are the main contract occasions to have permit if you’re gonna give a parent to the patient with any of these things what happens is the bleeding will get worsen and you’re gonna increase the mortality of that patient due to severe bleeding so there we go we came to the end of the video hope

You learn something new today if you like this video help me make more videos by donating me on which made simple the link is in the description of this video and as usual like share and subscribe to my channel thank you

Transcribed from video
Heparin | Anticoagulant | Blood | Pharmacology | Med Vids made simple By Med Vids Made Simple