This is an audio version of the Wikipedia Article:
Levy salbutamol also known as laval buda rahl is a short-acting beta-2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease copd evidence does not show that liebe salbutamol works better than salbutamol thus there may not be sufficient justification for prescribing it the drug is the r- enantiomer of its prototype
Drug salbutamol it is available in some countries in generic formulations from pharmaceutical companies including sip la diva and de among others medical use liva salbutamol x’ bronchodilator properties give it indications in treatment of copd chronic obstructive pulmonary disease also known as chronic obstructive lung disease and asthma like other bronchodilators
It acts by relaxing smooth muscle in the bronchial tubes and thus shortening or reversing an acute attack have shortness of breath or difficulty breathing unlike some slower acting bronchodilators it is not indicated as a preventative of chronic bronchial constriction comparison to sell buta mall a 2013 systematic review of the drugs used as a treatment for acute
Asthma found that it was not superior to albuterol regarding efficacy and safety in subjects with acute asthma the review concluded we suggest that level beuter all should not be used over albuterol for acute asthma level beuter all is notably more costly adverse effects generally leave a salbutamol is well tolerated common mild side effects include an elevated
Heart rate muscle cramps and gastric upset including heartburn and diarrhea symptoms of overdose in particular include collapse into a seizure chest pain possible precursor of a heart attack fast pounding heartbeat which may cause raised blood pressure hypertension irregular heartbeat cardiac arrhythmia which may cause paradoxical lowered blood pressure hypotension
Nervousness and tremor headache dizziness and nausea vomiting weakness or exhaustion medical fatigue dry mouth and insomnia rarer side effects may indicate a dangerous allergic reaction these include paradoxical bronchospasm shortness of breath and difficulty breathing skin itching rash or hives attic area swelling angioedema of any part of the face or throat which
Can lead to voice hoarseness or swelling of the extremities pharmacology mechanism of action activation of beta-2 adrenergic receptors on airway smooth muscle leads to the activation of adenylate cyclase into an increase in the intracellular concentration of three five cyclic adenosine monophosphate cyclic am p the increase in cyclic am p is associated with the
Activation of protein kinase a which in turn inhibits the phosphorylation of myosin and lowers intracellular ionic calcium concentrations resulting in muscle relaxation leave a salbutamol relaxes the smooth muscles of all airways from the trachea to the terminal bronchioles increased cyclic amt concentrations are also associated with the inhibition of the release
Of mediators from mast cells in the airways leave a cell viewed amal acts as a functional agonist that relaxes the airway irrespective of the spaz majin involved thereby protecting against all bronco constrictor challenges while it is recognized that beta-2 adrenergic receptors are the predominant receptors on bronchial smooth muscle data indicate that there are
Beta receptors in the human heart 10 to 50 percent of which are baited to adrenergic receptors the precise function of these receptors has not been established however all beta adrenergic agonist drugs can produce a significant cardiovascular effect in some patients as measured by pulse rate blood pressure and restlessness symptoms and/or electrocardiographic
Ecg changes approval and names leave a salbutamol is the end while level buda rahl is the usan lev albuterol was approved in the us as a solution to be used with a nebulizer device in march 1999 and in march 2015 became available in a formulation with a metered dose inhaler under the trade names open xhf a level view doral heartrate inhalation aerosol see also
Salbutamol the racemic mixture containing both our – + s + + auntie immers references
Transcribed from video
Levosalbutamol | Wikipedia audio article By wikipedia tts