𝗝𝗼𝗶𝗻 𝐨𝐮𝐫 𝘀𝗶𝗺𝗽𝗹𝗲 𝗰𝗼𝗻𝘁𝗲𝘀𝘁 𝘁𝗼 𝘄𝗶𝗻. Everyone wins a full electronic copy of Dr. Ergin’s diabetes book, and 𝘆𝗼𝘂 𝗰𝗮𝗻 𝘄𝗶𝗻 𝗼𝗻𝗲 𝘀𝗶𝗻𝗴𝗹𝗲 𝗶𝘁𝗲𝗺 𝗼𝗳 𝘆𝗼𝘂𝗿 𝗰𝗵𝗼𝗶𝗰𝗲 𝗳𝗿𝗼𝗺 𝗼𝘂𝗿 𝘀𝘁𝗼𝗿𝗲. 𝗬𝗼𝘂 𝗰𝗮𝗻 𝗵𝗮𝘃𝗲 𝗺𝘂𝗹𝘁𝗶𝗽𝗹𝗲 𝗲𝗻𝘁𝗿𝗶𝗲𝘀 𝗮𝘁 𝗼𝗻𝗰𝗲 𝘁𝗼 𝗶𝗻𝗰𝗿𝗲𝗮𝘀𝗲 𝘆𝗼𝘂𝗿 𝗰𝗵𝗮𝗻𝗰𝗲 𝗼𝗳 𝘄𝗶𝗻𝗻𝗶𝗻𝗴. 𝟭 𝗶𝗻 𝟮𝟬 𝗲𝗻𝘁𝗿𝗶𝗲𝘀 𝘄𝗶𝗹𝗹 𝘄𝗶𝗻 𝗮 𝗳𝗿𝗲𝗲 𝗶𝘁𝗲𝗺 𝗳𝗿𝗼𝗺 𝗼𝘂𝗿 𝘀𝘁𝗼𝗿𝗲. 𝐂𝐥𝐢𝐜𝐤 𝐡𝐞𝐫𝐞 𝐭𝐨 𝐒𝐓𝐀𝐑𝐓:
Metformin’s main pharmacological effect is it is the most controversial drug used for diabetes as well now recently there was a metformin recall does metformin really cause kidney damage what are the metformin alternatives what else can i take besides metformin right metformin was first shown to help diabetics avoid
Cancer in 2005 whereas early studies show that it affects a wide range of molecular pathways that play a role in the development of almost every type of cancer but other studies show that it works well with a wide range of other anti-cancer treatments like your chemotherapy if you already have cancer your
Radiotherapy your immunotherapy etc in addition that it can help prevent cancers metformin’s blood sugar levels as you all know that is mostly because it improves insulin resistance in the liver which is an organ that causes a lot of sugar production in your system and releases into your bloodstream and it also
Helps increase glucose uptake in your muscles so that your blood sugar goes down and also decreases the absorption of sugar from your intestine overall improves your insulin sensitivity it does that by activating protein kinase now that main target for this enzyme is mtor protein which is super important for
Cell growth and cancer dynamics now amp kinase stops the mtor from working which is very important in preventing cell growth and cancer in addition glucose metabolism is in the heart of the metabolic arrangement found in cancer cells so metformin primarily affect the glucose metabolism one of the things that metformin
Does is making cd8t lymphocytes more powerful and help them recover from exhaustion cd8 t cells are one of the most important parts of cellular immunity against tumors because these cells can attack cancer cells metformin was able to bring back that exhausted cd8 positive t lymphocytes back to life in the
Lab studies this has happened for leukemia this has happened in melanoma renal cell carcinoma carcinoma gastrointestinal cancers or even breast cancers metformin is the most commonly prescribed medication for treatment of diabetes in the world for diabetes as well in fact up to 90 percent of people have some sort
Of side effect such as diarrhea excessive gas bloating burping and so on now rare side effects can even include chest pain and liver failure and so on now sometimes common side effects are tolerable and sometimes they are not one of the most forgotten side effects is b12 deficiency again metformin may prevent the
Absorption of b12 in the intestinal system and ironically b12 deficiency can cause neuropathy and diabetes can cause neuropathy so you don’t a prolonged use of metformin now what are the other side effects sometimes cardiovascular side effects such as palpitations chest pain can happen some people complain about
Shortness of breath now general side effects some people will have like tiredness some people will be like weak and they will have muscle pains you know and that they may not know what’s going on because they may not attribute those side effects to metformin but it does happen dermatological side effects such
As skin manifestations sometimes skin eruptions can happen rest can happen with with metformin typically the most common and neurological side effects we can we can think of like a dizziness or headaches can happen with metformin as well and since most side effects tend to disappear effects so the way to start this is
Starting very small like 500 milligram and then another important thing is to start with your dinner empty stomach you’re going to be in trouble so take it with meal start with dinner take it for a week and see how it goes and if everything is good you don’t feel bad no side effects then maybe you can start
500 milligram twice a day with the breakfast and dinner this time again to summarize guys start slow start with meals start with dinner once a day only and then advance it twice a day maybe 500 milligrams twice a day and then advance to maybe a thousand milligrams twice a day b12 deficiency now what you do
With that so basically you just have met b12 checked maybe once a year or so or every other year it’s not really your b12 levels are not going to drain very quickly because b12 is a stored vitamin so i would not uh panic about that check your beat world if it is normal you don’t have to check it for another year but b12
Is very easy you can take your b12 supplement if you’re deficient if you have pernicious anemia you can take an recall now with the metformin recall i wouldn’t worry about this gmat because when there’s a drug recalled they’re gonna let your pharmacy know and pharmacy will call you now metformin recall does
Not mean that they recalled all the metformin in the world no that’s not true some metformin brands again there’s like a god knows 20 30 100 brands out there that make metformin because it’s the most commonly used medication in the market right now so uh some of the companies screwed up and if they figure that out very
Quickly immediately what are the metformin alternatives what else can i take besides metformin right let’s start with the simplest one the lifestyle change right well the studies have repeatedly confirmed that you can actually achieve diabetes control especially early stages by restricting calorie and carb
Intake because excess fat in the liver causes excess supply of fat in the pancreas which leads to impaired functioning of the pancreas which is the insulin producing hormonal gland in your body now reduced intake of calories not only decreases the production of glucose but also contributes to weight loss along with
The clearance of fat from the liver and pancreas what is your other option well excellent release metformin can be so most of you may never heard of that or some slightly more tolerable than regular metformin able to tolerate extended release metformin as well now berberine is an alternative to
Metformin as well right so berberine is a great diabetes supplement that is frequently used to treat type 2 diabetes not by the doctors but by the people berberine is a really good compound that can improve insulin sensitivity hundreds of different studies have been conducted to determine its effect on type 2 diabetes
And cholesterol and most of them pointing to metformin-like features amp kinase activation which is an enzyme it helps you improve your insulin resistance by making your own body breakdown glucose better and faster as a result of that your cholesterol also improves and your ldl the bad cholesterol also
Improves what else it does it also improves the gastrointestinal system by increasing the good bacteria and it helps to reduce the amount of carbohydrates that are absorbed or broken down by your body both berberine and meth vermin can cause gastrointestinal distress but berberine is less likely to do so so is there
Anything better than berberine right that’s the question is there such thing yes dehydroberberine is a superior form of berberine the hydrobarbarian’s chemical structure allows it to be more readily absorbable by the body and it reduces the side effects there are people may say alternative to metabolism but
Totally different than metformin and the side glyburide or glutamateride are totally different and worse they make your pancreatic cells make insulin all the time without taking a break causing long-term failure of your pancreatic beta cells you can still have even abdominal pain and diarrhea but the worst problems
Associated with sulfonylurea class is that it is low blood sugar pioglethazon is licensed fda approved for a long time it reduces the insulin resistance in the liver muscle and fat tissue as well and as a result you know your body will be able to uptake the glucose a lot easier so it is in a sense we call it an
Insulin sensitizer in a way similar to metformin although not exactly it does not have the gastrointestinal side effects of metformin but it does cause weight gain water retention or edema you can call it and a possible worsening of heart failure if you are taking that medication with insulin and a possible increased risk
Of bone fractures have been reported and a slight it does not directly cause kidney damage but what happens when you have a kidney failure because in excessive doses if metformin is not clear by your body there is something called lactic acidosis which can actually kill you now thankfully it is very very rare but i’m
Okay with stopping or reducing metformin as the kidney function goes down just to protect you from the possible lactic acidosis that happens with metformin but again you know we work with the patients you know if you don’t feel comfortable it is okay to stop it it’s not like the only medication in the market
There are a lot of ways to do it and if you are dedicated to change your lifestyle and do some exercise and dieting and change your lifestyle entirely that is probably the best thing you can do it may or may not be enough in every case every case is different but i think you have options as long as you know your options
And you’re educated and that’s why you’re watching this channel i think you have the odds to your favor guys make sure you like this video share and give a thumbs up and we’ll see in the next one metformin is an old drug that has been repurposed nowadays people who don’t trust metformin manufacturers due to frequent
Recalls etc turn into natural thing that the metformin does such as berberine or the more absorbable form of berberine which is dehydroberberine now it is good to see that overall results from clinical trials and studies have shown that both metformin and its natural cousins dehydrobarbarian etc protect against
A wide range of different types of cancer that’s a new hope great hope as of 2022 there are more than 300 clinical trials showing or trying to prove anti-cancer benefits of these agents and most have been successful so make sure you check out our website for super berberine and make sure you guys stay free happy
And healthy i’ll see you in the next video hey guys i hope you are enjoying this channel so far and i hope you subscribed already if you didn’t do it and if you did watch this video right there i think that will help you too
Transcribed from video
Metformin: What Happens If You Take Metformin For A Week? By SugarMDliveBroadcastDetails{isLiveNowfalsestartTimestamp2022-07-22T230015+0000endTimestamp2022-07-22T231320+0000}