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Hey what’s up everybody it’s the afro nurse and welcome back to another video so today we are going to be discussing naloxone alright so what is the pharmacological action of this particular drug so naloxone is an opioid antagonist so what exactly what does that mean so it blacks the effects of opioids like central nervous system depression and respiratory depression

Without producing any agonist effect so to put a bluntly you know to put it more simply it works against opioids old bo is still elicited somewhat of a not necessarily as a data effect but a pain relieving effect because they mimic the actions of our bodies endorphins so when naloxone does is that it blocks it blacks receptors and it limits the effect that opioids

Have on the body so kind of going aligned with the pharmacologic action the therapeutic action is that naloxone reverses the effect of opioid overdose so medication administration i have a lot of information on a screen feel free to pause it if you want to actually read through all of it i’m going to touch on a couple of things the first thing to notice is that

Naloxone can be administered in a lot of different ways it can be administered iv which is the picture that you see on the screen it can be administered as an auto-injector and it also can be a minister as a nasal spray in addition to those methods it can also be administered in terms of like the route so it can be administered iv like i stated before intramuscular

Subcutaneously and i do believe those are the last the the the main ones so iv intramuscular subcutaneous nasal and auto-injector if we can count that as intramuscular if you will go for particular reasons why the naloxone would be a minister for post-op opioid induced respiratory depression for opioid induced respiratory depression during chronic opioid use chronic

Meaning more than one week for overdose obviously of opioids and for opioid induced pruritus and for each of these there are set parameters and dosage for adults for children for neonates so again if you want to kind of pause it and read through the different administration’s you can go ahead and do that so what are contraindications for naloxone so the main thing

Is that if you’re allergic to the drug that’s a contraindication so hypersensitivity that’s something that we always want to make sure that we are aware of whom we are prescribing any type of medication now what kind of patients should this drug or should this opioid antagonist be used cautiously in well people with cardiovascular disease people that are physically

Dependent on opioids due to withdrawal or the possibility of withdrawal pregnant women because it may cause acute withdrawal syndrome and the mother and the fetus if the mother is opioid dependent and also in neonates as well because again it may cause acute withdrawal stand excuse me acute withdrawal syndrome a cluster of symptoms that occur for one or two weeks

When a person stops taking an addictive or prescription drugs and again this is again the mother was opioid-dependent what are the complications for an unlock zone so in terms of body systems it doesn’t necessarily affect affect a lot of different systems compared to maybe other drugs nevertheless and the cardiovascular system it can cause ventricular arrhythmias

Which is very serious as well as hypertension and hypotension in the genital urinate system destroyed can cause nausea and it can cause vomiting what are some drug interactions again this drug doesn’t have at least from my knowledge and from the sources i used davis drug id and there aren’t a lot of drug interactions or like herbal supplement interactions with

This drug that can cause problems or anything of that sort but what i was able to find as an alarm can precipitate withdrawal in patients physically dependent on opioids which kind of expects what we were talking about before pregnant women or neonates whole from mothers who were dependent on opioids larger doses may be needed to reverse the effect of other type

Of excuse me opioids like the apprentice rain torin all i’m pronouncing this wrong these words incorrectly but a couple of these drugs here and it also antagonize this post-operative populace which again obviously it’s the main effect of the drug so for my nurses that are watching what are some interventions that we should be aware of first thing you want to

Monitor a respiratory rate rhythm ndepth wanna monitor pulse ecg blood pressure and level of consciousness frequently for three to four hours after the expected peak of blood concentration patients receiving opioids for more than a week are extremely sensitive to the effects of naloxone so we want to dilute and administer in slow increments we want to assess the

Patient for signs and symptoms of opioid withdrawal again these are the symptoms and signs and symptoms include vomiting restlessness abdominal cramps increased blood pressure and temperature lastly lack of improvement could indicate a disease process or other non central nervous system depressants so that’s something that we will want to be aware of for a client

Education as medication becomes effective we want to explain the purpose and the effect of naloxone to the patient we want to instruct parents and caregivers in the florida or indy correct technique for using naloxone nasally and we also want to explain the purpose and the instructions of the auto-injector visio the desired outcomes for this drug include adequate

Ventilation following obe you access and finally alertness without significant pain or withdrawal symptoms and that is the end of this powerpoint for naloxone i want to say thanks for learning please like comment and subscribe for more content and until next time see ifrah nurse peace

Transcribed from video
Naloxone (Narcan, Evisio) | DRUG CARD FOR NURSING,PA,PT,MD STUDENTS. By John Azike JrliveBroadcastDetails{isLiveNowfalsestartTimestamp2020-07-06T040011+0000endTimestamp2020-07-06T041037+0000}