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Pharm2 Group 63 mefloquine

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Pharmacology 2 group video project on Malaria- Mefloquine

Malaria is a life-threatening mosquito-borne blood disease caused by plasmodium parasite just transmitted to humans through the bite of the femur and the filiz mosquito the mosquito is a vector of the malaria parasite an infected mosquito bites a human the parasite then multiplies in the hosts liver before infecting and destroying red blood cells over 1 million

People die from malaria annually and approximately 500 australians are infected whilst traveling there are various symptoms of malaria most commonly including fevers chills and muscle pain preventative measures can include wearing protective clothing using insect nets as well as the use of mosquito repellent are you thinking of traveling overseas a better solution

As a preventative and treatment method of malaria is the use of the drug mefloquine it’s used as an alternative to chloroquine resistant strains of the plasmodium parasite avoid traveling to malaria infected countries when pregnant as malaria can spread from a woman to a child do you have any allergies or other medications okay great old for scribing with clark

Wine that was best well but i’ve actually been on before i’m actually resistant did you have well you could actually use methyl wine that’s also good but i’ve also heard of doxycycline yes that’s good but that was more for prevention however mefloquine actually works for both treatment and prevention and it’s also used once weekly so you don’t need to worry about

Missing your dosage yes i can show you a little video of how it works mefloquine is an agent that is active against the erythrocyte ik stages of the plasmodium species however it has no effect against the exo air through civic stages of the parasite the plasmodium species converts heme from the hosts red blood cell to energy within the process heme is converted

To hematin which is a toxic compound hence it is then converted into hemas oil a non toxic compound mefloquine inhibits such a conversion which allows toxic levels of hematin to increase resulting in the death of the plasmodium it is very effective against malaria parasites resistant to chloroquine and in preventing malaria there are many clinical trials that have

Been conducted to assure the effectiveness of mefloquine since its discovery in the 1970s as the world needed it after the resistance developed for the use of chloroquine one study tested seven thousand one hundred and forty-eight patients in 18 clinical trials and treated them with different doses of mefloquine only nine adverse effects were reported it was then

Concluded that the tolerance of a single dose is moderate but can be improved by administering it as its victors over three days the study also reported effects of dizziness headaches nausea and vomiting for healthy volunteers another study tested a randomized group of a hundred and three adults and children to compare chloroquine and mefloquine the study shows the

High-grade chloroquine resistance to the parasites chloroquine had a high of failed treatment rate there has been a successful use of methyl kind mono therapy against chloroquine resistant strains patient treated with mclecklin showed a faster response to the treatment than chloroquine this is why patients should use methyl klein and it should be the preferred drug

Of choice the prolonged use of mefloquine is said to cause neuropsychiatric side effects such as nightmares and suicidal thoughts which can develop into chronic depression anxiety hallucinations or even schizophrenia however the efficacy safety and probability of mefloquine can not be ignored in 2015 91% of malaria cases recorded worldwide was situated in africa

And along with 65% of hiv cases unlike salsa dogs in praia de mean methyl weren’t compatible with this code try boxes all a hiv preventative treatment toss is significant in the core prevention of hiv and malaria further the increased susceptibility of pregnant women to malaria infection can be eliminated through chemo prophylaxis of mefloquine being a category b

Pregnancy drug mefloquine are one of the few anti-malaria drugs which do not cause adverse pregnancy effects including prematurity and stillborn hens the increase of accessibility to multiplying to low income and high malaria epidemic areas will end the cycle of malaria contributing to a malaria free world

Transcribed from video
Pharm2 Group 63 mefloquine By Sha May Koh