#AntiEpilepticsClassify Type Mechanism Of Action Classification Classify Epilepsy
So people we were looking at the classification of anti epileptic drugs we have seen the chemical classification and then we saw the clinical classification now by mechanism of action also we can look at the classification of anti epileptic drugs so basically the mechanism of action overall to tell you the neurons should be inhibited for this there are some ways
Of doing looking look at this diagram so as you can see here there are three things that can be done okay three things this much is clear three things can be done if your drugs diagram definitely they’ll be very happy you’ll be explaining the mechanism of action and also the classification right so here the sodium channels it can be inactivated so prolonged
The inactivation of sodium channel so that the neurons will not get into xi3 it will not get into excitatory phase you can also have the inhibition of calcium current inhibition of calcium current again this is a red thing you’re going to prolong the inactivation of sodium channel you are going to inhibit the calcium current okay and gaba is actually going
To be facilitated but gaba itself is inhibitory neuron so again this will be a red for the neuron so basically everything is trying to stop the firing correct off the signals so basically here there’s a prolongation of the sodium channel the inactivation the inactivation of the solar channel is prolonged here the cashing current is stopped and here the gaba is
Facilitated so gaba can bind when gaba binds there will be inhibition correct so all this is going to happen so sodium prolongation of the sodium channel inhibition of the calcium current facilitation of the gaba mediation facilitation of the gaba mediated calcium channel so the chlorine channel then gaba will bind and the chlorine channel will open what are
The drugs rotten or should you remember let us look at our favorite carbamazepine carbamazepine is coming here it is going to prolong the sodium channel inactivation carbamazepine you should know so first of all you focus on this one carbamazepine is important where exactly carbamazepine comes in sodium channel inactivation what about our next favorite sodium
Valproate sodium sulfate interestingly is doing all the three isn’t it great so sodium valproate is doing all the three sodium valproate is a carboxylic acid derivative and sodium valproate actually is going to be the first line of drug in what it is the first line of drug in absence seizures and myoclonic seizures right where is our third favorite in status
Epilepticus it status epilepticus you will give benzodiazepines and phenytoin phosphine turns so you should know this benzodiazepine is here benzodiazepine is here and phenytoin is here so benzodiazepine and phenytoin phenytoin is doing only one thing inactivation of the sodium channel please remember this phenytoin is just doing phenytoin is just in activating
The sodium channel for long okay benzodiazepine is facilitating gaba mediated calcium channel opening okay so in status epilepticus you are giving a combination of these two that is prolongation of the sodium channel and facilitation of the gaba mediated calcium channel sorry chlorine channel opening so remember phenytoin plus benzodiazepines are given in status
Epilepticus we are going to prolong the sodium channel in activation and the facilitation of gaba mediated chlorine channel opening okay the waters we should know let us see barbiturates always go in hand with benzodiazepine so they are also going to do gar bear me a facilitation then what about it all sucks my death row sucks and i it seems to be going with the
Calcium current because if they ask you classification because based on mechanism of action you will have to remember this it’ll suck some id is going to be off the inhibition of the t-type calcium current you should know this calcium current is stopped then you have the newer drugs newer drugs remember this vigor battering gabapentin tiga balin all of them have
To obviously be under gaba mediated right no doubt about that correct so is this easy you can write these three no something else is missing here one of them is missing which one gabapentin pregabalin pregabalin is not given here guys let us close this video please look at this there are three ways off for preventing epilepsy one is better elongation of sodium
Channel inactivation of cross prolonging the inactivation of the sodium channel facilitation of the gaba mediated chlorine channel opening and the inhibition of the t-type calcium current all these so all the three mechanisms are basically going to make the neurons fire less so as a revision let me see if you can answer sodium channels gaba and then calcium
Current inhibition so tell me oh where does carbamazepine comes carbamazepine comes here then you have sodium backplate which will work on all the three then you have benzodiazepine will let me just put it in order carbamazepine sodium valproate valproate valproate volka wait this one will be in all the three back through eight well oh wait and valproate will do
All the three then you have benzodiazepines and benzodiazepines bunzo die as the pines and barbiturates barbi to rates come here then you have phenytoin coming here phenytoin why am i writing like this because when zona is a pins and phenytoin are go hand in hand for status epilepticus barbituates can reap can work similar to benzodiazepines then you have ethos
Aksumite that will come in the calcium at who suck seam id will come here okay once again so a toe socks amide is a sixteen might okay then talking about the other drugs like gaba penton then you have tr tr garb in tr garb in correct then you have we got that b gaba true right it is thiago bean bigger battery okay anything else you want me to revise or everything
Is fine for you so we are closing this video guys hope you have understood everything
Transcribed from video
Pharmacology 413 d AntiEpileptics Type Mechanism Of Action Classification Classify Epilepsy By MBBS VPASS