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Physiologic Androgens & Inflammatory Kidney Disease + Progesterone for Myelin || BioNews #4

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Today’s papers:

Hello friends good morning and welcome to another day of bio news today i have about 10 papers to go through with you and they’re quite interesting to begin we have a paper by whites or vites at all this paper found that they found an interesting relationship between gaba and the reward effects of cocaine in the brain it found that number one administering

Cocaine to rodents reduce the postsynaptic gabaergic inhibitory currents uh in the um rodents brains so taking cocaine a dopaminergic drug that inhibits the reuptake of dopamine and causes dopamine transmission and noradrenaline transmission with noradrenaline is norepinephrine it’s like adrenaline in the brain think of it like you know speed in the brain um it

Causes those things to be released and caused there in i can talk about in uh reuptake inhibition in a future episode but basically it increases these excitable things in the brain and naturally you would think by doing that it would reduce the inhibitory stuff in the brain so we know that the interesting thing also though is increasing the inhibitory activity

In the brain the gabaergic activity also reduces even the reward potential of cocaine by limiting that dopaminergic effect natural but interesting to note molodini at all produced a paper in which they studied um in humans the effect of supplementation with one species of bacteria and one pre prebiotic they compared supplementing the bacteria by itself or

With the prebiotic and they did this specifically in people with coronary artery disease and what they found was this and by the way the species called the lactobacillus aromnosis g which is a very common species you can find online on amazon if you’d like and the prebiotic is called inulin inulin was significantly uh synergistic when added with uh the bacteria

Bacteria not synergistic i didn’t mean that i meant it added more value i’m not sure if it was synergistic um because we can’t read the full paper yet but what it did do was reduce c-reactive protein which is a measure of c of systemic inflammation it’s a protein released by the liver which is a good thing it reduced tumor necrosis factor alpha which is an

Inflammatory cytokine released by the immune system when it thinks it’s being damaged or attacked which often happens in coronary artery disease and it reduced imagine subjective scores of depression and anxiety among the human patients that had the disease significantly just the addition of the bacteria with the prebiotic so fantastic paper very interesting

Highly recommend reading it i will certainly be reading it in detail when it’s out myself a paper by turner at all very interesting studying worldwide actually i think this was um this was in the west americans yeah yeah studying america there have been a lot of worldwide surveys of depression and anxiety in kovid apparently i wasn’t aware of them this is

The first one i’m reading but this was in the us and the results follow through with some in china and in other places in the world what they found was the most susceptible people to depression anxiety from the change in the living situation that we have are women and specifically young women which explains why i’ve been noticing that lucy has been suffering

My wife has been suffering a lot with this uh situation unfortunately you know she’s pregnant so this really affects i’m very concerned because it really affects the baby you know the the mentality of the mother really affects the baby and women i think are quite susceptible young younger women are apparently according to this people the most susceptible in

Fact the average uh rates of generalized anxiety disorder according to these surveys online from papers from psychiatrists are 30 in the worldwide population both of generalized anxiety disorder and major depressive disorder that’s really really high that is an epidemic of mental health and i knew this was happening but i didn’t read any papers about it it’s so

Interesting to see it confirmed another paper by spurnie at all this paper studied the effects of the use of nssri called escatalopram which by the way is an ssri i don’t like at all but it’s very clean it’s not the worst ssri there are very bad ones there are some that antagonize sigma receptors like sertraline which is ridiculous because the sigma receptor if

You antagonize it you reduce dopaminergic function further you wouldn’t want to do that unless you have like bipolar disorder or something like that anyway so there are a bunch of ssris but this one studies 10 milligrams of eschalopro and what they’re trying to see is in humans by the way and what they’re trying to see is this 66 people they’re trying to find

Out was because ssris do this right they inhibit the reuptake of serotonin in the brain what does that mean you have but let’s talk about inhibition of reuptake you have two cells in your brain these are called neurons they have hormones that they secrete send to each other to tell the other cell to do something this hormone goes and this other cell may have

A receptor for that hormone or it may not if it doesn’t it’s not going to recognize the signal if it does like a it may have a gaba receptor or a glutamate receptor gaba is an inhibitory neurotransmitter slows the other one down glutamate excites it it’ll have a receptor and it’ll feel it now what does a reuptake inhibitor drug do it lets your first neuron

Signal that that hormone it doesn’t tell your brain to release more of the hormone necessarily like cocaine inhabits reoptic but also causes your brain to release hormones and ssri is selective to serotonin and it does not cause a transmission of serotonin some of them relative drugs do but this one doesn’t so what does an ssri do it tells that second cell

Don’t let go of the hormone because your body doesn’t feel serotonin that well so you need to feel it a little bit more like me so what does it tell your body hold that serotonin hold it so that’s what a selective serotonin reuptake inhibitor does it makes you feel serotonin a bit more and the reason it works is because when it does that just like psilocybin

And lsd do that’s why people microdose them it downstream to that that effect causes an increase in brain derived neurotrophic factor in your brain which is a growth factor and that provides an antidepressant anti-inflammatory anti-anxiolytic which is anti-anxiety effect in your brain but ssrs also do something else people will notice that at medium and

Even higher doses of ssris they will feel more inhibition they’re not taking the benzo they’re not taking valium or xanax but it doesn’t feel like that but you’re a little bit more inhibited look at my older videos for example and compare them to right now the speed of uh speech that i have for example you’re a little bit more inhibited the question is is that

Because serotonin downstream in inhibition of reuptake of serotonin downstream causes an increase in gabaergic activity or does it inhibit excitatory activity like glutamate well basically this paper by spurning it all showed maybe i’ll go into a bit of details basically it showed no evidence of gabaergic increases but evidence of glutamate decreases glutamate

Excitatory function decreases specifically it showed a reduction in hippocampal but not thalamic like your hypothalamus glutamate activity previous papers had shown a decrease in glutamine activity in the prefrontal cortex in the first week but uh and and i don’t know if they showed a decrease in the occipital uh cortex i might not actually have a mistake

Here so i can’t tell but anyway the problem is these papers you know you can’t read them yet they’re very new so that’s why i just give you guys brief things about them um a paper by ruler at all showed that both dopamine 1 and dopamine 2 receptors both play a role in attention in the brain of course as you guys know most of the drugs prescribed to people

Have attention problems or dopaminergic drugs they try to make them less addictive by making them slightly less dopaminergic but those ones are actually worse drugs usually like methylphenidate and these kind of drugs but it turns out both receptors are important this is something important to note because some people sometimes use dopamine agonists something

Sometimes people use antipsychotics that block one receptor and not the other so it’s important to note that both of them are important in memory uh otani at all have a oh very interesting paper this is a mouse model of a disease called autoimmune glomerulonephritis which is what autoimmune kidney disease which potentially i’m not sure could be what chris

Bumpstead has i have to ask but uh potentially that could be what he has his autoimmune system i’ve heard is attacking his kidneys so in this mouse model rodent model i don’t know yeah mouse model they showed that castrating the mice uh not going not taking a mice from super physiologic levels of androgens taking a mouse from normal male levels of androgens

To zero by castrating it reduced the glomerularly glomeroscopic severity with glomerulosquattic means when the glomeruli in the kidney start to break and develop scar tissue around them so it reduced the severity of that indicating that even physiologic levels of androgens worsen the severity of the autoimmune sort of kidney disease which is interesting because

I was thinking that it did it mostly through growing the kidney but it actually does it also through the autoimmune disease which is fascinating a paper by yang at all very interesting so it studies acabia saponin d this uh this phytochemical benefits metabolic diseases it’s been shown in various studies including obesity atherosclerosis and nafld but it’s only

0.13 percent bioavailable orally so how does it do that so that’s what the authors were questioning and they thought that maybe it does that by changing the microbiome so they performed the study and what they found out was asd this is a acabia saponindi asd altered the microbio biome promoting these species butry simonas rumino caucus befidobacterium allostipes

And privitola the last two alice tipis and previtola may promote inflammation and metabolic syndrome they may not be great but the first two butry simonas and romino caucus both convert glucose into the fatty acid butyrate which you guys have heard from me before if you’ve seen my video called sodium butyrate changing two percent of your genes with a supplement

That is an uh histone d acetylase inhibiting fatty acid short chain fatty acid that is produced by the microbiome and it provides energy to the microbiome and lowers the local ph on now we get onto this ph subject that we’re discussing with jerry branham local ph in the gut reducing the growth of pathologic bacteria that grow in apparently different uh higher ph

Levels bifidobacterium preserves gut barrier functions what is gut barrier functions your your intestinal lining has a mucosal lining on the inside and that prevents your bacteria from harming your actual intestines and more specifically from your body thinking your bacteria is attacking you from the inside and sending inflammatory cytokines like tumor necrosis

Factor alpha to attack your intestines like what happened to me when i got crohn’s disease so then this is why it’s so important to study these species of bacteria and why i’m so i have such a specific uh regimen with my probiotic supplements and why i’m always keeping track of this so um anyway then conclusion is that asd may promote may um attenuate metabolic

Syndrome by improving the health of the microbiome agnello at all and by the way i’d like to you guys to know this microbiome studies it’s all in its infancy we’re going to learn so much in the next 10 years it’s such an exciting time period to be interested in this agnello at all have a paper on tau in als so if you guys don’t know in alzheimer’s disease

There’s two main pathologies in the brain that cause the actual oxidative stress and damage in the brain that causes the neuronal cell loss that eventually causes the dementia that causes what you see as alzheimer’s where they can’t remember things but there’s actually two pathologies in their brain for example in parkinson’s disease there’s something called

Alpha acinocinoclicino protein something like xeno sy something like that that’s the kind of protein that they pathologically deposit in their brain that causes damage in alzheimer’s disease they have two kinds one is called beta amyloid plaques these are made from well we’ll actually get into them later beta amyloid plaques and then they have something called

Those are extracellular then they have intracellular what are called tau tangles now tau is a protein that is produced in all people what they found in this study is that and by the way when tau is hyper phosphorylated it can turn into this insoluble aggregate that i call the intra what’s called a neurofibrillary tangle the neurofibular tau tangle but anyway

The interesting thing about it is this they discovered that als patients my grandmother died of als a year and a half ago stephen hawkings has died of als you guys are probably familiar with that famous disease als by the way guys if you’d like to know more about that disease i studied it a lot myself it’s a disease in which very interesting so your brain has

Something called axons axons are like these like uh i always call them tentacles because i’m you know i never studied biology in school by the way i did study science just to make clear because some people keep commenting that i didn’t study science no i studied science but i didn’t study biology so i anyway i don’t know what i’m talking about so it’s they

Look like tentacles in the brain and they send neurotransmitters through the brain these axons are covered in what’s called myelin which is a lipid-rich sheath that increases the capacity of these axons to function not only increases it’s necessary structurally for their function in the in the disease of als these myelin the myelin production reduces and these

Axons degenerate eventually the person loses control of their body now um a couple of notes on this number one my grandmother died of it so i’m very concerned about it number two progesterone signaling at the progesterone receptor is one of the best ways to increase the speed of myelin production synthesis in the body which is one of the reasons i tell everybody

That’s on trt to be on hcg because you’re bald you’re sorry your gonads are what produce your progesterone mostly and you need progesterone and people like me i mean i have hcg now i’m thinking of going on it i haven’t taken the plunge yet but if i go on hcg i will immediately begin supplementing progesterone the only reason i’m not is because it’s a negative

Feedback signal to the hypothalamus and the produce the production of gonadotropin releasing hormone so but but progesterone signaling increases the rate of myelin synthesis in fact by the way the only while we’re on this topic the only be careful don’t use a synthetic progestogen you see in europe they give women micronized progesterone as a contraceptive

But in the us they give them progesterogens and progesterogens are all associated with cancer development except for one called segesterone acetate which unfortunately you can only really find in brazil for some reason when it’s not with estrogen or with something else anyway the point is and in the disease of als what they found is that uh this was really off

Topic but i hope this was helpful they found that als patients had higher levels of total tau proteins in their cns and had lower phosphorylated tau to total tau ratios showing that it could be used as a biomarker for als in a paper by he at all uh they studied the anti-epileptic drug zone semite i don’t know pronounce it zonisamide you guys may be familiar

With anti-epileptic drugs if some of you have had consultations with me there are some of my favorite medications for people who have inhibitory problems in their body that don’t want to take ssris because they’re not usually as addictive or as concerning as gaba receptor modulators but these things often either increase gaba in the brain in total like some of

My clients are on sodium vaporite for example or they for like this drug for example decrease like this drug decreases basically glutamate glutamatergic activity excitatory activity for example here it inhibits voltage-dependent sodium and calcium channels uh decreasing the likelihood of action potential generation and stuff like that and spontaneous firing

And so on in the brain because it does that it produces an anti-apoptotic effect in the brain it preserves mitochondrial function of dopaminergic neurons it has an antioxidant effect it increases brain derived neurotrophic factor nerve growth factor neurotrophic receptor kinase 2 expression and it does this of course by reducing the overall excitatory activity

In the brain the more excitement you have in your body the more oxidative stress you have the more you go on marathons the more damage you’re causing to your body is the same in your brain so if you just slightly increase what we call neuroscience is the excitatory to inhibitory ratio the e to e the e to i ratio if you increase decrease the e to i ratio you can

Preserve some brain function so in this study they used zonisimide uh on um to to show that they could inhibit glucose and oxygen dependent apoptosis and ameliorate neurological deficits and reduce infarct volumes in a rodent model of ischemia where you ischemia is like a stroke in a rodent model and finally a paper by lee edol and this paper is a review paper

As i told you guys before i will not cover review papers very often but this one is nice this paper just summarizes phytochemicals that have been shown in other papers to reduce the synthesis of the precursor or the pathways to amyloid beta synthesis amyloid precursor protein synthesis which is app which is the protein that is then used to produce amyloid plaques

In the brains of alzheimer’s these patients remember they have tau and amyloid anyway so i just want to list these two to you guys really quickly there’s two pathways there’s a secretase dependent pathway and a structure dependent pathway the structure-dependent pathway resveratrol has been shown to do this brazilian from sapan wood has been shown to do this

Curcumin tannic acid from oak and thief laven from black tea the secret taste dependent pathway legus tilaide has been shown to do this ginsenoside from ginseng has been shown to do this tdc from licorice root has been shown to do this by the way i take licorice root i take ginseng i take resveratrol i take curcumin i take tannic acid i take the eflavin just

Let you guys know and then and then we’ll just continue the list for secret days hespidin i don’t take that i take berberine i take egcg and then they include uh poly methoxy flavones from citrus peels and black ginger so guys that’s my summary for bionews for i’ll see you guys soon hope i wasn’t too boring you know maybe maybe not everything can be followed

But hopefully some some stuff is interesting i’m a little bit all over the place that’s just how i am with with stuff i like to talk and go on tangents hope you guys are patient with me see you guys soon have a great day you

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Physiologic Androgens & Inflammatory Kidney Disease + Progesterone for Myelin || BioNews #4 By Leo and Longevity