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protective effect of telmisartan … the first AE work ..

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this is an experiment done in KFU , college of medicine in Al-Hasa ..

Cisplatin is one of the most effective chemotherapeutic agent that is extensively used for the treatment of ovarian testicular bladder lying and breast carcinomas however and for toxicity is the major adverse effects are presenting at those a limiting factor and cisplatin therapy there is a substantial evidence supporting the rule of reactive oxygen species and

The lipid peroxidation and neuronal damage that developed in response to sis 14 tilma certain is an angiotensin ii receptor antagonist used for treatment of hypertension recently it was demonstrated that the tilma xerton had a significant antioxidant activity and protected against oxidative tissue and during different experimental models the present study was

Performed to evaluate the protective effect of tilma xerton against disability in india scenario toxicity the rats were randomly assigned to three groups the first group received a single interpret any of those of normal saline and served as a control group nephrotoxicity was induced and rats of the second and third the groups by a single intraperitoneal injection of

Cisplatin 20 milligram per kg the second and third the group animals received daily enter peritoneal injection of 1% eco solution of 10 mr. tintin milligram per kg respectively for six consecutive days starting three days before cisplatin administration seventy-two hours following cisplatin administration the animals were sacrificed and blood samples were collected

And centrifuged for 10 minutes at 5,000 rpm the obtain zira where stored at minus 20 siliceous til the levels of blood urea nitrogen and serum creatinine were determined using color metric assay kids according to the manufacturer’s instructions following blood sampling the kidneys was removed washed and cold saline kept at minus 80 cities yes and we’re subsequently

Homogenized and called potassium phosphate buffer the homogenates we’re centrifuge at 5000 rpm for 10 minutes at force elisa’s the supernate was used for determination of oxidative stress biomarkers melon delta hide reduced glutathione levels and catalyst activity at the nitric oxide level as have crew inflammatory mediator using polymeric sa kits as indicated by

The manufacturer the left kidney obtained from each animal was fixed in ten person firmly solution dehydrated in ascending great of alcohol and embedded and perforin sections at four micron thickness we’re taking stained with hematoxylin and using solutions and under light microscope the cisplatin induce elevations and blood urea nitrogen and serum creatinine

Levels were significantly reduced to the normal values by tilma certain treatment also tilma certain significantly reduce the include mulund aldehyde and the nitric oxide levels and restored the reduce glutathione level and catalyst activity in neuronal tissue accessibility in treated animals those three figures show the photomicrographs of the kidney rats the

First photo micrograph is for the control group which shows the normal renal architecture the second photo micrograph is for the group that received cisplatin and shows renal tubular necrosis interfacial edema and intraluminal casts while the third photo micrograph is for the group that is treated by tilma certain and shows remarkable improvement and histologic

Picture with absence of cisplatin induce severe necrosis edema and cast formation the present study demonstrated that tilma certain provided a significant neural protective effect against cisplatin induced acute renal damage therefore tilma certain can be considered as a potential candidate to minimize the spotting of toxicity which is a major and dose-limiting a clinical problem

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protective effect of telmisartan … the first AE work .. By abdulazezmukhizem