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Sanofi – Better understanding insulin

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Insulin is a hormone which plays a key role in the regulation of blood sugar levels. A lack of insulin, or an inability to adequately respond to insulin, can each lead to the development of the symptoms of diabetes. Watch this video for an overview on what insulin is.

Insulin is an essential hormone made by beta cells in the pancreas a small amount of insulin is continuously released from the pancreas throughout the day when we eat more insulin is released into the bloodstream where it helps glucose from the food to enter into cells to be used as energy insulin was discovered in 1921 by a team of researchers from the university

Of toronto in canada in 1923 sir frederick banting and his team received the nobel prize in medicine for this milestone discovery which has revolutionized both the therapy and the prognosis of the diabetes after a hundred years of use insulin is now very well known people with type 1 diabetes don’t make any insulin if we have type 2 diabetes the insulin we

Make cannot work effectively and or not enough is produced over time our pancreas often gets tired and produces less and less insulin because the glucose cannot get into cells properly it begins to build up in the blood and leads to hyperglycemia over a long period of time high glucose levels in our blood can seriously damage our heart and cardiovascular

System our eyes our kidneys and our nerves especially in the feet whatever the type of diabetes the goal is to normalize blood sugar levels close to 100 milligrams per deciliter before meals for people with type 1 diabetes it is necessary to take insulin for type 2 diabetes lifestyle changes such as healthy diet exercise and weight loss can be enough to keep

Diabetes and blood sugar under control if not there are many treatments that may help during the last 100 years great strides have been made help millions of people with diabetes taking insulin to live life to the full and to help avoid or minimize the complications of diabetes animal insulin from cows was the first type of insulin to be given to humans by

Injection to help control diabetes as it’s nearly identical to human insulin then human insulin which was better tolerated was produced by recombinant dna technology the gene for human insulin is inserted into a bacteria or yeast which can make this insulin thanks to the multiplication of this bacteria or yeast enough human insulin is produced and can be used

After purification the structure of insulin or how it’s formulated has been modified to more closely mimic the body’s own normal insulin response and action profile there are different types of insulin to cover the body’s insulin needs that differ in terms of time of onset and duration of action three main types exist a rapid or short acting insulin will cover

The body’s insulin needs at meal time taken before or during meal times they help to use the carbohydrates in the food rapid acting insulins have an onset of action of between 10 and 20 minutes after injection a peak action of one to two hours and a duration of action of four to six hours short-acting insulins have an onset of action of about 30 minutes after

Injection a peak action of two to four hours and duration of action of six to eight hours you also have intermediate acting insulins that reach the bloodstream two to four hours after injection have a peak action of around four to ten hours and a duration of action of around 12 to 18 hours the first generation of long-acting insulins modified from human insulin

Have no pronounced peak and their goal is to cover basal insulin need over a 24-hour period second generation basal insulin analogues are also available and have a longer duration of action that goes beyond 24 hours they are given once a day based on the patient’s needs long-acting intermediate rapid or short-acting insulin can be administered using disposable

Or reusable pens or syringes shortened rapid-acting insulins are the only insulins that can be used in a pump for people with diabetes who require insulin it helps them keep their blood sugar and diabetes under control so they can live their lives to the fullest you

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Sanofi – Better understanding insulin By Sanofi