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Sodium Glucose Cotransporter-2 (SGLT-2) Inhibitors For Type II Diabetes

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SGLT-2 Inhibitor Class for Type II Diabetes.

Hi my name is thuy vaughn i’m gonna be talking about a class of medications called sglt2 also known as sodium-glucose cotransport are two inhibitors so to start off we have patient consultation you should take this medication in the morning and this medication can cause increase urination and dehydration which can result in dizziness lightheadedness weakness

Fainting and thirst this medication can also cause a rare but serious condition called ketoacidosis so make sure to let your doctor know if you develop nausea vomiting or feeling tired or stomach pain so infection of the urinary tract can occur while taking this medication so let your doctor know if you have any burning or pain when you urinate a need to urinate

Frequently and urgency or if you have pain in the lower part of your stomach or blood in your urine especially if you have a fever and another serious but rare condition is that the medication can increase your risk of like and foot amputations so to introduce the sglt2 inhibitors they are an oral diabetes medication class they have desirable side effects for type

2 diabetes patients such as weight loss and reduction in major cardiovascular events and immortality there are four main medications that can uncuff losen invokana dipaola frozen for zija impala frozen guardians and are to go phazon mystic lateral the indication is for type 2 diabetes patient as an adjunct to die an exercise to improve glycemic control and also a

Risk reduction of cardiovascular mortality in adults with type 2 diabetes and establish cardiovascular disease and also this class of medication decreases a1c from 0.7 to 1% so in terms of dosing and adjustments these medications are dose based off a gfr so the invokana is a hundred milligrams daily part first meal of the day it can be increased to 300 milligrams

Daily if the patient has egfr between 45 to 59 max dose is a hundred milligram and if it’s less than 45 there are not recommended to take the medication for the far zija five milligram daily in the morning they can increase that 10 milligram daily and if their egfr is less than 60 it’s not recommended guardians 10 milligrams daily in the morning you can increase to

25 milligram daily if egfr is less than 45 then it’s not recommended as for the sturgill at row 5 milligram daily in the morning and then if egfr is less than 60 then it’s not recommended so the mechanism of action is that the sglt2 inhibitors are expressed in the proximal or renal tubules they’re responsible for reabsorption of filtered glucose from the tubular

Lumen they inhibit sglt2 these drugs can reduce reabsorption of filtered glucose and lower renal threshold for glucose this increases urinary glucose excretion and decreases plasma glucose concentrations for the side effects of these medications there is a black box warning of risks of leg and foot amputations so we need to evaluate the risks prior to treatment

So if the patient has a history of amputation a peripheral artery disease peripheral neuropathy and our diabetic foot ulcers there’s going to be weight loss for the patient hypoglycemia increased urination increase in thirst and increase in museum phosphate and potassium monitoring parameters include renal function blood glucose a1c ldl blood pressure and volume status

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Sodium Glucose Cotransporter-2 (SGLT-2) Inhibitors For Type II Diabetes By Riverside Rx Services