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Hello … This video Regarding Classification of sympathomimetics in easy & simple way.

Hi students welcome to pharmaceutical youtube channel and today is our discussion on sympathetics sympathetic is nothing but its classification so i hope you know sympatho sympathomimetics are drugs nothing but they mimics the action of sympathetic neurotransmitter against the sympathetic nervous system so what are the sympathetic neurotransmitter the neurotransmitters

Like adrenaline under noradnaline sympathetic neurotransmitter category okay so these drugs mimics the actions of this sympathetic system so sympathetic neurosystem nothing but the sympathetic nervous system contains hydroenergic receptor alpha adenosine receptor as well as beta adversity so both alpha as well as beta administrative receptors are belongs to g

Protein couple receptors and the sympathetics agonize mimics the action of this alpha beta receptors in the sympathetic nothing but adrenergic system so here the first a general classification of sympathometrics so for our understanding purpose the general classification of sympathomimetics is these are direct acting drugs these are mixed acting trucks just a second

So here direct acting drugs as well as mixed acting drugs as well as indirect acting drugs indirect acting drugs so here regarding direct acting drugs means this drugs acts on the receptor so here the drugs directly interacts with the receptor it may be alpha receptor it may be beta receptors it is depend on the drug as well as its selectivity and in this the drugs

Directing category the drugs interacts with receptor they may be selective category they may be non-selective character next in case of second category is mixed acting drugs the example of mixed acting drugs like ephedrine as well as pseudoephedrine so pseudo epidrin efficient efficient both the stereo chemistry the difference the difference between both are just

Stereo chemistry so what is mixed acting drugs the mixed acting drugs having the action of direct interaction with receptor as less they are also having the indirect action so because of that the category of drugs are called as mixed actin drugs the examples like ephedrine as well as pseudo-epitope next category is indirect acting drugs so here indirectly acting

Drugs these drugs does not directly interact with the receptors this drug does not directly interact with the receptors these drugs initially increase the cataclysms and after the increase in catecholamines that catecholamines directly interact with the receptors in case of direct attack index they after enter into the body they directly interact with the receptors

But in case of indirect acting after entry into the body first they increase the catecholamines like dopamine norwegian in different ways after that that increased catacombs binds to the receptors so in this category of indirect actin inductor there are four different categories these four different category drugs ultimate action to increase the catecholamines

But in different ways so we will see what are the different ways first one is drugs increases release of catecholamines the examples like amphetamine which is a generally cn stimulant as well as tyramine tyramine is a chemically monoamine it is generally present in the food substance like diary products like milk like cheese so these two drugs increase the release

Of catecholamines from the pre synapse next uptake inhibitors so uptake inhibitors wants a neurotransmitter for example here adrenaline so once a neurotransmitter is completed reaction from the post synapse to again it go back to the pre-synapse for the storage purpose or for the termination of its action once neurotransmission action completed it have to be

Terminated by using uptake that is called as reuptake mechanism so for the pre-synapse to portion ups neurotransmitter will come to show its action once after its completion of action again it will go back by using uptake mechanism that is called as reuptake mechanism so here the drugs like cocaine as well as tricyclic antidepressants tricyclic antidepressant

Generally used in that depression so this cocaine as well as tricyclic antidepressants inhibit the uptake of catecholamines and increase the catecholamine levels at the post-synaptic receptors nothing but target tissues next monoamino oxidase inhibitor so monoamino oxidases are the enzymes responsible for the catacombines metabolism or catecholamines degradation

If the catecholamine degradation increases sorry catecholamine degradation decreases then catecholamine levels are increases so examples like salicyline as well as rasa jalen these are selectively blocks the mono amino acids bnj and prevent the metabolism of catecholamines especially dopamine next co empty inhibitor catechol o methyl transferase catechol o methyl

Transferase so when this enzyme is inhibited catecholamines metabolism reduce it so because of inhibition of both monoamino oxidase as well as catechol or methyl transphase then catecholamines are unable to degrade unable to metabolize catecholamine levels are increasing so here as we know that indirect actin drugs initially they increase the catecholamine levels

In different ways and after that included catecholamines interact with the receptors so this is a general classification of sympathomimetics based on its action direct acting mixed acting as indirect acting the next classification is based on each receptor so all these are sympathetics all the sympathetics agonize the alpha as well as beta adenosine receptors

By acting on the sympathetic nervous system okay the next is after general classification based on selectivity of the each receptor based on selectivity of the each receptor so we will go through that so here this column is belong to the receptor and here these are the select organist and these are the non-selective agonists so first regarding alpha receptor

Regarding alpha receptors for for regarding alpha receptors and their location their function you can go for our previous pseudo on the identity receptors what is that magic receptors how many types their locations their functions so here the alpha 1 receptors are generally present in the black vessels so the select two agonists on the alpha one receptors like

Phenyl ethne methoxamine middle drain and non-selective organisms on the alpha one receptors nothing but alpha receptors like metaraminol as well as oxymetazoline as well as xylo metal so apart from alpha 1 receptor they may also bind to the other receptors that’s why these are categorized into the non-selective economist next alpha two receptors alpha two

Receptors the examples of alpha two receptors like uh clonidine select two alpha two receptors chloride alpha two receptors generally present in the presynaptic neurons of the central nervous system the clonidine methyl dopa dexamethamidine brimonidine so clonidine methyl dopa generally for the antihypertensive purpose decimated dexmeditomidine is a generalistic

Category brimonidine used in the glaucoma and regarding non-selective category apraxim after our clonidine having interaction with alpha receptor maybe it can also interact with alpha and receptor also maybe other receptors it comes under the category of non-selective category so next beta1 receptor i hope you know beta1 receptors are located in the majorly

Myocardium apart from the myocardium nothing but cardiac muscle they are also located on the glomerular apparatus of the kidney so the select two agonists on the beta 1 receptors of myocardium like a dopamine denominator xamotherol as well as pranoltellar so apart from these four ducks though bitumen is commonly used in the clinical application to increase the

Heart activity to promote the cardiac muscle contractions just a second so after completion up to beta 1 receptors next towards the beta 2 receptors next towards beta 2 receptors okay so beta 2 receptor location in the on so here beta2 receptors select to again is like a formoterol sol material solve beta mall term beta as well as level butyron which is

Also called as livo solving so the examples of select two beta two receptor regulation select two beta two receptor are you used in the treatment of asthma so these drugs causes relaxation of the bronchial smooth muscle and controls abnormal respiration in the asthmatic patient and feel free asthma from the patient nothing but gives feeling to the patient free

From asthma and non-selective drugs like a rito drink as well as isosceles okay so this is the category of drugs acting on the beta2 receptor and next receptors are beta-3 receptors so beta-3 receptors are generally present on the adipose tissue as well as urinary bladder also urinary bladder so here the selective drugs acting on beta-3 receptors so me background

Mira background solar background so all backgrounds if you find any new drug with background for example tomorrow roller background so definitely it is beta 3 receptor agonist and this all backgrounds like me background mirror background solar background these three drugs selectively agonize the beta 3 receptors present on the urinary bladder so this is a simple

Classification of sympathetics i hope you enjoyed it and regarding the application of sympathetics you can watch our videos also thank you keep following our channel for more interesting concepts

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