This video is about the synthesis of an essential drug, levodopa. Levodopa is used in the treatment of Parkinson’s patients. It’s a precursor of dopamine, a neurotransmitter in the brain.
Oscillation reaction in the first video you have seen the synthesis of aspirin where i have shown how escalation occurs yeah in this video i’m going to show you the feeder curve oscillation reaction levodopa so leave the power where or when or in patients for the uh the parkinsonism patients patients who suffer
From parkinson’s diseases they they lack dopamine yeah the the the real cause of this uh deficiency in dopamine uh is really not yet to be uh discovered they still don’t know the exact cause of it so is that is by giving them a little bit of the precursor of dopamine and usually it’s given in grams
Actually uh for the to the patient what happens is that liberal part okay can diffuse into the uh brain through the the blood brain barrier and it turns into dopamine and that helps in terms of supplying or providing dopamine to the patient and helps in terms of normalizing the level of development in in the brain so now
Let’s have a look at these and this is oblivious and we going to start with liberto the name actually came from the uh the l form of um this drug yeah uh and what is the l form the alpha will be you have this yeah in front coming out of the paper and that hydrogen at the back there all right and this is actually
You can synthesize the uh thyrosine yeah you can uh first like slightly backward so instead of me showing step by step from starting to the end bottom so we already have we know what we want to synthesize we want to synthesize labor dopa so we’re going to start with starting material from the bottom here so here
I’m going to write here we’re going to start with this um what we’re going to do we’re going to do this this chloride if you remember that to choose lecture about the friday curve alkylation yeah you would straight away you probably uh guess what you’d get at the end yeah uh in here what we’re going to do because
This is the friday calf assilation yeah but what happened is that so this will react with the um ring here all right so what we’re going and this photograph escalation is very specific to the to the aromatic ring okay so this what will happen is that it will add on molecule is including the oxygen the carbonyl group okay
It’s this group if you see it’s like you know just a simple estimation it is you are right if you think that it’s just an acetylation yeah uh is this adding on the astar group um but if you compare with the first video where you have the escalation of the oh group of the sales and acid the difference here is that this
Particular group the aster group is added to a aromatic group yeah so what we have here is we’re gonna have okay so once we have that already this the n product that we want yeah the drop okay but what happens is that now we we don’t want the on the benzene ring here to the oh group all right so to do that so in
The presence of this reagent what happens that it will then um the acid delay yeah the this is a d assimilation you will remove this ester in the synthesis of liver dopa there are many ways to synthesize lipid apart this is only two steps okay two steps all right so first what happens is that we this we’re gonna
With yeah acetal chloride and then so this is the classic photograph oscillation all right when this compound has been treated with this acetylchloride you will add on that acetal group onto the aromatic ring at this point you is that this is a carbon carbon-carbon bond reaction whereas in the aspirin the estilation
Is a carbon oxygen bond reaction okay so in here the aromatic hydroxyl group yeah so we treat this molecule with hydrogen peroxide and sodium hydroxide naoh and that will de-acetylate estilation that’s the first step and the second step we have to give our liver dopa all right
Transcribed from video
Synthesis of Essential Drugs | LEVODOPA By ACE That Preso with Dr Aisyah