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Hey there i’m connected please and the next one who will present after me is yurio kinese my cousin we are both related because we are both rhombolytics we will be both discussing about organic drug classifications pregnancy category mechanism of action pharmacokinetics indications contraindications adverse and side effects and are nursing responsibilities for

My drug name my generic name is synectoplase and my brand name is tnks and metallize and my chemical name is now for my drug classification in my therapeutic class i am a thrombolytic and in my pharmacologic class i am a recombinant tissue plasminogen activator a pregnancy category is seen where in animal studies have revealed evidence of maternal and embryo

Toxicity when given multiple iv doses there are no well-controlled studies in human pregnancy for my mechanism of action my chemical effect is that i bind to fibrin and convert plasminogen to plasmin specificity to fibrin decreases systemic activation of plasminogen and the resulting breakdown of circulating fibrinogen and my therapeutic effect is that i dissolve

Blood clots my formal kinetics is that absorption is given through iv the distribution is related to weight and is an approximation of plasma volume metabolized by liver and the excretion is unknown and i have a half-life of 20 minutes to two hours and the onset is immediate my indications reduction of mortality from acute myocardial infarction for adults weighing

Less than 60 kilograms then give 30 milligrams of 6 ml by iv bolus over 5 seconds for adults weighing 60 to 69 kilograms give 35 milligrams 7 ml by iv bonus over 5 seconds now for between 70 to 79 kilograms give 40 milligram 8 ml by iv bolus over 5 seconds swinging 80 to 89 kilogram give 45 milligram 9 ml by iv bolus over 5 seconds and lastly give 50 milligram

10 ml by iv bolus over 5 seconds to adults weighing 90 kilograms or more the maximum dose is 15 milligrams to function indicate that with persons who have hyper sensitivity arterial venous malformation aneurysm active bleeding intracranial or intraspinal surgery or trauma within two months cns or central nervous system neoplasms severe hypertension severe renal

Or hepatic disease history of cva and increased icp or stroke precautions to pregnancy breastfeeding children geriatric patients arterial emboli from left side of the heart hypocoagulation subacute bacterial endocarditis rheumatic valvular disease cerebral embolism or thrombosis or hemorrhage in arterial diagnostic procedure or surgery within 10 days recent

Major surgery dysrhythmias and hypertension and side effects in the central nervous system is fever intracranial hemorrhage and stroke now in the cardiovascular system my adverse and side effects are cholesterol embolism coronary reperfusion arrhythmias major hematoma and minor hematoma now in the hematology bleeding at function sites for the eyes ears nose

And throat is epistaxis and pharyngeal bleeding in the genital urinary system is hematuria the last part that we will be discussing about me the nursing responsibilities for assessment you must assess the underlying condition before starting therapy and be assessed regularly to monitor drugs effectiveness ken is monitor the electrocardiogram for reperfusion

Arrhythmias third assess pain before therapy and reassess regularly fourth is assess patients and family’s knowledge about drug therapy we are finished with assessment so let us proceed to nursing diagnosis first diagnosis is an effective tissue perfusion coronary related to presence of good second is acute pain related to myocardial infarction third deficient

Knowledge related to the nectar-based therapy in the planning and implementation first minimize arterial and venous punctures during therapy second avoid non-compressible arterial punctures and internal jugular and subclavian venous punctures third monitor patient for bleeding if serious bleeding occurs then immediately stop giving heparin and anti-platelet drugs

It is cholesterol embolism which is rarely related to thrombolytic use but may be lethal signs and symptoms may include levido reticularis purple toe syndrome acute renal failure gangrenous digits hypertension pancreatitis mi cerebral infraction spinal cord diffraction retinal artery occlusion vowel infarction rhabdomyolysis teaching teach the patient or family

About proper dental care to avoid eating and is teach them to not defy a prescriber of bleeding hypersensitivity fast or slow or uneven heart rate feeling of faintness blood in urine stools and nosebleeds third explain the use of drug to patient and family evaluation patient regains tissue perfusion with the solution of blood clots second patient is relieved

Of pain and lastly patient and family states the understanding of drug therapy i’ll be giving the platform to my cousin i am europe nate my brand names are canalitic and the bookending my chemical name is i have two drug classifications first is the therapeutic classification which is thrombolytic and the pharmacologic classification which is an enzyme i am

Categorized as category b in pregnancy category because there are no welding studies of me that have been done in ems but in animal studies i am given the pregnant animals and the babies did not show any medical issues related to me my chemical effects is that i activate plasminogen by directly cleaving peptide bonds at two sides and my therapeutic effect is

That i dissolve blood clots in lungs coronary arteries and venous scattered ears my absorption route is through iv and my distribution is rapidly cleared from circulation and i am mostly accumulates in kidneys and liver i am metabolized rapidly in the liver skirted small amount in urine and bile and my half life is 10 to 20 minutes my onset is immediate and my

Peak is 20 minutes to 2 hours with a duration of 4 hours for my indications license of acute massive pulmonary emboli and pulmonary emboli accompanied by unstable hemodynamics for adults for iv infusion only by constant infusion pump priming those is 4400 kilograms over 10 minutes followed with 4 400 kilogram per hour over 12 hours flush any of my remains in

The ivy chipping with a volume of compatible iv solution about equal to that of the tubing at 15 ml per hour for venus cafeteria occlusion and adults instill 5000 international units into occluded cafeteria for my contraindications i am contraindicated in patients with active internal bleeding aneurysm arteriovenous malformation bleeding diathesis visceral or

Intracranial cancer ulcerative colitis diverticulitis severe hypertension hemostatic defects enclosing those secondary to severe hepatic or renal insufficiency and control the hypocoagulation surveillance bacterial endocarditis or riamatic valvular disease history of stroke recent trauma with possible internal injuries fluorescence cerebral embolism thrombosis or

Hemorrhage i am also contraindicated within 10 days after intra arterial diagnostic procedure or surgery such as liver or kidney vibe c lumbar puncture thoracium decels parasynthesis are extensive or multiple cat dots and within few months after intracranial or intraspinal surgery i am injections and other invasive procedures are contraindicated during neurokinase

Therapy for adverse and side effects my adverse and side effects in cns are fever hemiplegia and stroke for cardiovascular are reperfusion arrhythmias tachycardia transcend hypotension or hypertension for gi or nausea and vomiting for hematologic bleeding for respiratory are bronchospasm and minor breathing difficulties for skin are leviticus and rash and for

Others are anaphylaxis and chills for nursing responsibilities assess patient’s condition before starting therapy and regularly thereafter to mandatory my effectiveness assist patient for contraindications to therapy monitor patient for excessive bleeding every 25 minutes for first hour every 30 minutes per second through 8 hours and then once every shift

Free treatment for me affecting weight loss places patient at higher risk for bleeding monitor pulse rates and color and sensation of limbs every hour clip the rotary flow sheet in patients chart to monitor ppt pt inr hemoglobin leaf level and hematocrit we alert for adverse reactions and ma and drag interactions assess patients and fabulous knowledge for drug

Therapy for nursing diagnosis and effective tissue perfusion cardiopulmonary peripheral related the presence of blood clots and effective protection related to drug induced breathing deficient knowledge related to drug therapy for planning and implementation half type and cross smash rbcs and amino carbohydrate acid available to treat cd and keep corticosteroids

Available to treat allergic reactions give venipuncture sides to a minimum use pressure dressing on puncture size for at least 15 minutes keep blimp being treated in alignment to prevent bleeding from infusion size don’t handle the patient unnecessarily bad side drills brushing is more likely during therapy to prevent recurrent thrombosis start hampering by

Continuous inhibition when patient’s thrombin time has decreased to less than twice the normal control value after urokinase has been stopped for patient bleaching instruct patients to report symptoms of bleeding and other adverse reactions for the evaluation patient regains normal tissue perfusion with the solution of blood glass patient doesn’t experience

Serious complications from drug induced bleeding and patient and family state understanding of drug therapy that would be all we hope you learned something thank you god bless you

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TENECTEPLASE AND UROKINASE by Sano and Yunson By Batch Kunzite