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Hello my name is jennifer burley and i am a pharmd candidate of the class of 2022 and today i will be discussing terazosin also known as hytrin i will begin by discussing a brief overview of terazosin terazosin is in the drug class alpha-1 blocker it is an anti-hypertensive agent and the indications for terrazosin include benign prostatic hyperplasia and

Hypertension now i will discuss the mechanism of action of terrazosine terazosin is an alpha one adrenergic receptor blocker that specifically blocks alpha 1 receptors alpha 1 receptors are found in smooth muscle tissue which include vascular smooth muscle sphincter smooth muscle and urinary bladder smooth muscle and can also include the prostate blocking

These receptors in the prostate leads to reduce symptoms and improve urine flow for men who have benign prostatic hyperplasia next i will discuss adult dosing for terazosin the first indication is benign prostatic hyperplasia or bph the patient would initially take one milligram oral capsule once daily at bedtime and then the dose would be titrated slowly

Every few weeks from 2 milligram and 5 milligram and then finally 10 milligram based on patient response and tolerability the usual dose is 10 milligram once daily but if there’s no response after four to six weeks of 10 milligram once daily then the patient may increase to a maximum dose of 20 milligrams once daily for the indication hypertension initially

The patient would take one milligram oral capsule once daily the dose will be titrated gradually as needed based on patient response and tolerability up to a maximum of 20 milligrams per day in one to two divided doses now i will discuss formulations and dosing adjustments for terazosin the generic comes in oral capsules and they are available in one milligram

Two milligram five milligram and ten milligrams the brand name hytrain has been discontinued there are no renal dose adjustments required and there are no hepatic dose adjustments required some common adverse effects of terrazosine include dizziness nausea increased heart rate swelling or puffiness and hands feet or lower legs myasthesia headache weakness low

Blood pressure drowsiness blurry vision and nasal congestion now i will discuss some serious adverse effects of terrazosine this includes allergic reactions such as a rash fever or shortness of breath priapism low blood platelet count irregular heartbeat and an intraoperative floppy iris syndrome which is the condition where there is a loss of muscle tone in

The iris of the eye patients should seek immediate medical attention if any of these adverse effects occur now i will discuss warnings precautions and conjure indications associated with terrorism intraoperative floppy iris syndrome has been observed in cataract surgery patients who were on or were previously treated with alpha-1 blockers such as terrazosine

Taking this medication may impair physical or mental abilities therefore patients must be cautioned about performing tasks that require mental alertness such as operating machinery or driving taking this medication may cause significant orthostatic hypotension and syncope especially with the first dose or the first few days of therapy of terezosin a sudden drop

In blood pressure may also occur if the therapy is interrupted for a few days the dosage is rapidly increased or if another anti-hypertensive drug is used along with terrazosin priapism has been associated with patients who are taking terrazosin and although it is rare a patient should seek immediate medical assistance for erections lasting longer than four hours

Prostatic carcinoma cancer should be ruled out before beginning therapy with terazosin due to many symptoms of bph benign prostatic hyperplasia and prostate cancer are very similar terazosin has been determined to be an agent that can may exacerbate underlying myocardial dysfunction in heart failure patients as well patient education of terrorism patients should

Take this medication at bedtime especially the first dose because it may help prevent syncope or loss of consciousness it is important to take this medication at the same time every day as directed by your doctor avoid activities requiring mental alertness or coordination until you know how terrazosin may affect you because this medication may cause dizziness

And someone else rise slowly from a sitting or lying position because terazosin may cause a sudden drop in blood pressure from rising too quickly avoid sudden discontinuation of this drug because this may cause rebound hypertension avoid alcohol while taking terrazosine and if you miss a dose of terrazosine take the drugs as soon as you remember unless it is

Close to regularly scheduled dose then just take one dose do not double or take extra doses of terrazosine next i will discuss monitoring parameters for terazosin these include standing and sitting supine blood pressure especially following the initial dose at two to four hours following the dose and thereafter blood pressure should be checked regularly with a

Target blood pressure of less than 130 over 80 is recommended and then improvement and urinary symptoms should be monitored as well these are my references thank you for listening to my presentation

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Terazosin By Riverside Rx Services