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We think because we’re reducing the amount of carbs that we eat or we’re watching our sugar intake that we’re totally scot-free of any potential issues when it comes down to insulin resistance well doesn’t seem to be the case you see fats can actually influence insulin resistance too and this is a little bit sketchy because it kind of throws a wrench in a lot of
What we look at but if we understand the kinds of fats we understand the amounts and we understand the basic physiology it can help us out a bunch i’m talking mainly about palmitate okay a type of saturated fat that you’re going to find in most meats and a lot of cheeses and things like that okay now we have to understand first of all there is this thing called
Hmga hmga is a nuclear factor which means it activates gene transcription for insulin receptors an insulin receptor is where insulin ultimately binds to okay so if insulin receptors are not being created then you have less places for insulin to bind to which can certainly lead to insulin resistance because the insulin has nowhere to bind now what does saturated
Fat have to do with this in general well excess saturated fat has been linked to a sustained down regulation in the expression of insulin receptor genes what this means is that when we overeat saturated fat which by the way is very easy to do especially on a low carb protocol it actually changes the gene expression so we don’t produce as many insulin receptors
There was an interesting study it was published in cellular physiology and biochemistry and it looked specifically at this it looked at skeletal muscle tissue and it found that skeletal muscle tissue cells that were treated with palmitate with saturated fat and then exposed to insulin well there was a 2x decrease in the occupation of insulin receptors meaning that
Half the insulin receptors weren’t even receiving the signal from glucose anymore after there was a lot of saturated fat in the equation okay what is potentially going on here if we understand it we can fix it hey i put a link down below for thrive market first and foremost okay before we get into the science that is a 30 discount link okay they’re a big sponsor on
This channel and because you’re watching this video you can save 30 off your entire grocery order so if you go online to thrive market use that link down below just stock up your grocery cart get everything shipped to your doorstep but you’re gonna save 30 off your entire grocery order plus get a free 50 gift when you use that special link that is a very exclusive
Link for people that watch my channel so you’re gonna save 30 off no matter what you choose keto foods fasting type stuff paleo foods vegan whatever it doesn’t matter it’s all there down below in that link so there was a study that was published in diabetes obesity and metabolism found this very interesting because it was a post-mortem study so it took a look at
People that had passed away and they hypothesized that approximately 50 percent of the insulin producing cells have already died by the time people are diagnosed with diabetes what this means is that we’re not really producing insulin properly even by the time most people are diagnosed now what does this have to do with this whole saturated fat equation well
It actually tells us a lot more of everything you see when we produce insulin producing insulin is a product of receiving energy from fuel so it is our fuel supply whether it’s glucose or fat or anything that ultimately fuels a pancreatic beta cell which produces insulin okay so glucose or fats they will fuel that pancreatic beta cell and it will load up with
Atp and it is a load up of atp that ultimately allows insulin to secrete okay here’s where things get wacky normally these pancreatic beta cells get a signal from glucose and that fuels that cell enough to secrete insulin triggers the cell to secrete insulin if these pancreatic beta cells are constantly marinating in fats okay especially saturated fats because
They take a longer time to break down what happens is they have so much fuel already from the fat that when a signal from glucose comes in it’s a not even a big deal they don’t respond to it they have been bombarded so much with fuel from energy dense fats that when glucose comes into the equation they’re like whatever i barely need fuel i’ve got fuel from fats
Already in other words the response to glucose is significantly attenuated essentially there’s no need for the energy from glucose so it means that we’re still producing insulin we’re just not really producing insulin in response to glucose as well this is exactly why taking a little break from high fat diets every now and then is very important it doesn’t matter
Whether you’re keto or not taking a break from food in general can help restore this and that’s what’s interesting because there’s a study that was published in the journal diabetologia that took a look at this they did an eight-week severe caloric restriction study where they put people on a 600 calorie per day diet that is a lot of energy restriction they found
Within the first seven days it restored their insulin levels and it restored their fasting glucose levels within seven days they also found that there was a decrease of intra-hepatic lipids so basically liver fat by 30 percent and they found they were ultimately able to restore beta cell function so my point in saying this is that it’s the overeating of foods but
Especially the overeating of calorically dense foods such as saturated fat that can trigger this beta cell unresponsiveness but it is entirely fixable by changing the makeup of our diet periodically so with great power comes great responsibility if you’re going to eat a lot of saturated fat and a lot of ribeyes i’m not saying it’s the end of the world but you
Do need to flip that on its head now and then and allow yourself to regain beta cell responsiveness that is your responsibility otherwise you can absolutely develop insulin resistance while being on a ketogenic or lower carb protocol here’s something that’s very interesting though there is also something called saturated fat induced apoptosis this is where so
Much saturated fat is in the picture that it actually causes the cell to die it actually triggers apoptosis premature cell death and what happens is non-esterified fatty acids that come in from consuming way too much in the way of fats basically so much fats the body just doesn’t have time to deal with them you have circulating nefas non-estradi fatty acids these
Non-esterified fatty acids can actually cause damage to what’s called the endoplasmic reticulum which is kind of a house for protein and calcium things like that to make matters very simple it causes a massive influx in the cytoplasm of calcium this influx of calcium in the cytoplasm causes oxidative stress and can actually cause the cell to die this can absolutely
This is a beta cell right it can affect how much insulin we produce because the beta cell is essentially dying early not able to produce insulin but there is a fix to this or a preventative there’s a study published in the frontiers of pharmacology that found that oleic acid okay like that you would find in good quality olive oil this can actually prevent the
Damage from the saturated fat in the first place they found that monounsaturated fats taken in alongside saturated fats actually negated and reversed the negative effects of the saturated fat now researchers hypothesize it has to do with the antioxidant content of the olive oil okay so oleic acid has high potency antioxidants in it okay we’ve got all kinds of
Different mechanisms there that could be acting upon that are actually preventing the cellular damage that is occurring from essentially the lipid toxicity of so much saturated fat one of the things i know you’re wondering is okay well how much saturated fat is the right amount regardless of what diet you’re doing okay whether you’re keto whether you’re paleo
Whether you are high carb and you still have fats 10 of your total calories tops should be coming from saturated fat okay it just when you look at the insulin resistance piece it’s a very important factor to weigh in there’s even some studies if you look at a ketogenic diet specifically they took a diet that was ketogenic that was high saturated fat and low
Poly unsaturated fat and then they compared that to low saturated fat with high polyunsaturated fat not only did they find that the lower saturated fat group produced almost three times as many ketones okay that’s awesome they also found that it negated the potential insulin resistance issue they actually improved insulin sensitivity by having lower saturated fat
And higher polyunsaturated fat on a ketogenic diet and then they also found that it ended up decreasing or not increasing rather their cholesterol the lipid profile so it’s like okay if you’re doing low carb and you’re mad at me for doing this video because i’m talking about possibly lowering your saturated fat intake consider what we’re after do you want to eat
Your saturated fat or do you want high ketones do you want insulin sensitivity and do you want a nice lipid profile i mean i’ll eat my ribeye until i’m blue in the face don’t get me wrong but if i can throw some good quality polyunsaturated fats in there to negate the potential negative aspects of that i absolutely positively will so it’s kind of sketchy when we
Understand that it’s not just carbs that influence insulin resistance we do have to look at the big picture we’re learning something new every day i’ll see you tomorrow
Transcribed from video
This Increases Insulin Resistance by 50% (eat less than 25g per day) By Thomas DeLauer