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They have a wide range of uses, across multiple organ systems. adrenergic drugs are commonly used in shock or acute hypotension. here our goal is to increase blood pressure, so that perfusion is restored. the reason is that if the drug has only alpha now, the increased vascular tone and blood a decrease in cardiac output, and impairment of tissue perfusion. this increases
Blood flow, but at the same thus, there are disadvantages to using selective drugs. and β1 mediated cardiac stimulation, helps tendency to decrease cardiac output by α receptors. now let’s talk about a few specific types of shocks. dobutamine, and dopamine at low to moderate doses, stimulate β1 receptors. dopamine has additional action on dopaminergic receptors as well.
It increases blood pressure, counteracts bronchospasm, in neurogenic shock, there is a loss of sympathetic vasoconstrictor tone. mephentermine and ephedrine can be used in this situation. this is hypotension, occurring on standing when you stand up, normally the reflex control but in conditions where reflex control is so gravitational pooling of blood produces to treat this,
We can use drugs with α action, a newer agent droxidopa is a prodrug, that these drugs increase peripheral resistance, however this is a general action, and they now let’s talk about uses, where local vasoconstriction is needed. adrenaline is used in epistaxis, and noradrenaline cocaine is sometimes used in nasopharyngeal local vasoconstriction produced by epinephrine, so
The anesthetic agent stays local, which for this purpose, epinephrine is used in 1 in two hundred thousan dilution. as decongestants, they are used for colds, rhinitis, sinusitis, and blocked nose or eustachian drugs commonly used for this indication, are now, there are several disadvantages of these nasal decongestants. on prolonged use, ischemia leads to atrophy of mucosa.
Include naphazoline, xylometazoline, and oxymetazoline. also, they should be used cautiously in hypertensive so these were all the uses for local vasoconstriction. here, adrenaline given intravenously, along isoprenaline can be used temporarily, to maintain ventricular rate. however, dopamine or dobutamine, may be used during myocardial infarction, cardiac surgery, now
The last cardiac use, the dobutamine stress test. for this, dobutamine is infused intravenously at an increasing rate. because of this increased workload, the ischemic electrocardiography, or nuclear medicine techniques. here adrenergic drugs are used in bronchial asthma, and copd. it dilates the pupil that clears the view to see the fundus. in allergic conjunctivitis,
It decongests conjunctiva. apraclonidine and brimonidine are selective drug, with topical prostaglandin analogs, or β blockers. during pregnancy, the number of β2 receptors increases in the uterus. however, there is a risk of maternal cardiac in most allergic reactions, histamine plays a major role, and the adrenaline is a physiological the useful actions from adrenaline
Are vasoconstriction, however, it is not effective in delayed, and so this was about the use of adrenaline in allergic disorders. cental uses include attention deficit hyperkinetic adhd is common in children, and is associated but the reduction in appetite, may lead to growth retardation. amphetamines can help with this, but there modafinil on the other hand, has less
Chance now let’s quickly see some additional uses of adrenergic drugs. it can also be used in diarrhea in diabetics hot flushes, and to decrease craving for narcotics, dexmedetomidine is used for sedation in intensive and it lowers opioid requirements for pain tizanidine is an α2 agonist, and can be used as a central muscle relaxant. however, this is associated with so
Many side effects. bleeding from the skin and mucous membrane, along with local anesthetics, as nasal decongestants, asthma and copd, fundus examination, allergic syndrome, glaucoma, to postpone labor, threatened edema, anaphylaxis, urticaria and angioedema, you can find notes and explore our entire if you like our content, please share it with thanks for watching, see you in the next video.