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USMLE Pharmacology- Muscle Relaxants

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All right and so this section is sort of bad and cleanup it was lumped with the cholinesterase inhibitors and other paralytic agents which i including in the autonomic section because they’re sort of traditionally mentioned in that sense these are a few of the other drugs that were mentioned in that lecture i have two slides and i have a few facts that i’ve

Pretty much taken directly from the information that was included in your lecture i don’t really see these i would know a few facts about these next few drugs but i wouldn’t worry too much you have all of antibiotics all of the autonomic nervous system and all of these other things that you have to know and then a dermatological as well this this is this is these

Two slides or the last two slides you should study and for good reason because they’re agents that are adjunct that are used in different things that we’re going to talk about in more detail later i don’t know why they were introduced here so we start with diazepam diazepam is a benzodiazepine works on it see i have to like go in and do explaining what a die as

It depends what i have pain is we’re gonna talk about it later don’t worry too much about these so the benzodiazepine was a specific receptor that is a chloride channel you want to know that by a benzodiazepine when it activates the benzodiazepine receptor it increases the frequency of the channel opening it’s me mostly used for sedation and memory loss effects

But it can be used for muscle relaxation and it’s very very bad at that it’s historically been used for muscle relaxant but doesn’t really do a good job as opposed to some of other agents side effects as i just said it can be used for sedation or a supportive it can be used for sedation and you know so what it will cause sedation and then as we’ll get into in the

Future lectures that can cause respiratory depression baclofen another muscle relaxant this one it’s a gaba mimic it doesn’t necessarily it sort of acts like the neurotransmitter gaba and through this effect can cause muscle in effect wouldn’t worry too much about its mechanism right now we’ll explain that in the lecture down the line what i would know is baclofen

In your mind ms spasticity baclofen ms spasticity that’s what it’s used for those are the patient population that you’ll see it used in it can cause drowsiness not as much as diazepam but it is a little tolerant and there’s an apparent withdrawal syndrome that can occur if you take the drug away too quickly without titrating it that can lead to fever and altered

Mental status and rebound spasticity is a nadine this is an alpha-2 agonist we talked about a few before clonidine alpha methyl dopa this is another one that can be used and it can reduce muscle spasms it can cause drowsiness hypertension dizziness and dry mouth a couple anticholinergic side effects we have gabapentin pregabalin these are both antiepileptic drugs

They have some spasmolytic activity that’s all i would know i would know vamp name recognition for most of these and maybe for diazepam and baclofen knowing a little bit about you know baclofen zeusie ms and die of diazepam is effect on the chloride channel don’t expect much to be asked on any of these drugs here and then we have botox i talked about before and

Finally there were a few other drugs she talked about cyclobenzaprine carisoprodol i metallic sewn methyl carbon mole the parent drug is cyclobenzaprine so again it’s it’s structurally similar to tricyclic antidepressant we’ll talk about those drugs later it’s primarily used for muscle spasm and the side effects they can be very anticholinergic and sedative so you

Have to be careful when you give it to a patient who’s already on other said it is actually i believe it’s either i think it’s curse or protal it can be mixed with i think xanax and oxycontin oxycodone and opioid and you know it’s known to potentiate the effects and so a lot of drug users or will try to get their hands on this specific cars pro it all with xanax

And other drugs and mix them together because it can potentiate effects so it hasn’t has drug interactions with other sedative agents lastly big drug interaction with tricyclic antidepressants because their model these drugs are all structurally similar to tricyclics one of the things that the tricyclic antidepressants do is lead to qt prolongation which is that a

Ventricular repolarization and it can elongate that and if we have too many drugs that are elongated your ventricular repolarization you can possibly go into torsades so that’s a big interaction to know again didn’t really put too much information down for these last two slides i really wouldn’t worry too much about these two sides study these two slides last i’d

Save the last few nerve cells for for these two slides

Transcribed from video
USMLE Pharmacology- Muscle Relaxants By The Pharm Guys