When ACE inhibitors like captopril and enalapril are used for long term periods, serum potassium levels should be monitored due to possible hyperkalemia induced by these category of drugs. As theyse drugs reduce renal functionality, potassium levels may accumulate in the body.
Why potassium levels should be monitored in patients using ac inhibitors ac inhibitors are going to decrease the blood pressure as well as they are going to increase the potassium so is the revelation between this increase potassium and their mechanism obviously the answer is no the increased potassium is because of their renal action so first of all we will
See how the reading is released and how these acn ace inhibitors or in walk the release of reading is because of condition like hypotension in the body when the blood pressure is decreased it results in the decrease renal perfusion pressure which will stimulate the activation of the training and retention system now this activated in angiotensin system will
Release the grainy now this religion training then converts the angiotensinogen to angiotensin 1 which is then converted to angiotensin 2 by ac enzyme angiotensin converting enzyme now this angiotensin 2 can increase the blood pressure so easy ribit herbs are continued beta ac enzyme thereby they control the blood pressure you can see here these invaders are not
Related with any potential levels by this mechanism what is the role of this ac angiotensin converting enzyme in kidney within the kidney the glomerular filtration is connected by the glomerulus which is a network of capillaries this glomerulus is getting the blood supply from the efferent arterioles and after filtration the blood is going outside as the different
Arterioles so this one of the filtrate is them going into the renal tubules which is going to be excreted as urine now the intra globalnoc pressure is equal to the pressure difference between the different – f not radios so the rate of nominal filtration of alumina filtration rate depends on the intra glomerular pressure so as the intraocular pressure increases
The global filtration rate increases so for an effective global filtration rate the afferent arteriole should be dilated and different arterioles should be constricted when the afferent is dilated and different is constricted the internal pressure is going to increase which increase the glomerular filtration rate so the dilatation of the afferent arterioles is
Mediated by prostaglandin item which is also called as prostacyclin and similarly constriction of the different dr. jaws is mediated by angiotensin ii so now these two are the important mediator sighting on the renal system where they are going to produce the vessel dilatation of the efferent arterioles and vasoconstriction of the efferent arterioles so drugs
Like ana signs are going to inhibit the synthesis of the prostaglandins thereby inhibit the vasodilation produced by prostaglandin i too similarly drugs like ez inhibitors and er b’s angiotensin receptor blockers are going to inhibit the synthesis and action of the angiotensin ii thereby any bit of vasoconstriction on the efferent arterioles in this way all
These three candy drop drugs like ana sites ace inhibitors and er base can produce the decrease in the glomerular filtration rate on long-term use and they can precipitate the renal failure so ace inhibitors affect the renal function so when the ace inhibitors are used they are going to decrease the renal functionality so he is inverters and yabbies on long
Term use they decrease the glomerular filtration rate which can decrease the renal function thereby they decrease the excretion of the potassium leading to hyperkalemia the raised potassium levels in the body so that is why when these drugs are given for a long-term use we have to monitor the potassium levels at the same time drugs like potassium supplements and
Potassium sparing diet eggs should not be given with these rags as potassium supplements and potassium sparing deities can increase the further risk of the hyperkalemia produced by ace inhibitors and erps so in this way whenever his inverters are used for a long-term period the potassium level should be carefully monitored to avoid the hyperkalemia thank you for watching this video
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Why potassium levels should be monitored with ACE inhibitors? By egpat